4-tert-Butylperoxy-1-(4-methoxy-phenyl)-4-methyl-1-phenyl-pent-2-yn-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-tert-Butylperoxy-1-(4-methoxy-phenyl)-4-methyl-1-phenyl-pent-2-yn-1-ol
• 英文别名: 4-tert-butylperoxy-1-(4-methoxyphenyl)-4-methyl-1-phenylpent-2-yn-1-ol
• 化学式: C₂₃H₂₈O₄
• 分子量: 368.473
• InChiKey: IJCLFNHZGBCWQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基二苯甲酮 、 3-methyl-3-tert-butylperoxy-1-butyne 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.5h， 以78%的产率得到4-tert-Butylperoxy-1-(4-methoxy-phenyl)-4-methyl-1-phenyl-pent-2-yn-1-ol
  参考文献：
  名称：

  摘要：

  A procedure was suggested for the synthesis of 2,5-dimethyl-2-tert-alkylperoxy-5-lithiooxy-5methyl(phenyl)-5-naphthyl(aryl)alk-3-ynes by the reactions of the corresponding monosubstituted peroxyalkynes with butyllithium, followed by the reactions of the resulting lithium peroxy acetylenides with 4-methoxybenzophenone and 1- and 2-acetonaphthones. Lithium peroxy alcoholates are hydrolyzed with water to form peroxy-containing alcohols and react with methyl iodide in the presence of dimethyl sulfoxide to form the corresponding 2,5-dimethyl-2-tert-alkylperoxy-5-methoxy-5-methyl(phenyl)-5-naphthyl(aryl)alk-3-ynes. The thermal stability of the peroxides prepared was evaluated by thermal analysis.

  DOI：

  10.1023/a:1025696705051

文献信息

• ——
  作者：E. A. Dikusar、E. V. Vashkevich、N. G. Kozlov、V. I. Potkin、K. L. Moiseichuk、O. I. Isakovich、A. P. Yuvchenko

  DOI：10.1023/a:1025696705051

  日期：——

  A procedure was suggested for the synthesis of 2,5-dimethyl-2-tert-alkylperoxy-5-lithiooxy-5methyl(phenyl)-5-naphthyl(aryl)alk-3-ynes by the reactions of the corresponding monosubstituted peroxyalkynes with butyllithium, followed by the reactions of the resulting lithium peroxy acetylenides with 4-methoxybenzophenone and 1- and 2-acetonaphthones. Lithium peroxy alcoholates are hydrolyzed with water to form peroxy-containing alcohols and react with methyl iodide in the presence of dimethyl sulfoxide to form the corresponding 2,5-dimethyl-2-tert-alkylperoxy-5-methoxy-5-methyl(phenyl)-5-naphthyl(aryl)alk-3-ynes. The thermal stability of the peroxides prepared was evaluated by thermal analysis.