2-(Prop-2-enoyloxy)tridecane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(Prop-2-enoyloxy)tridecane
• 英文别名: tridecan-2-yl prop-2-enoate
• 化学式: C₁₆H₃₀O₂
• 分子量: 254.41
• InChiKey: WXHDEQKXLXTYRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PERCUTANEOUSLY ABSORBABLE PREPARATION, PROCESS FOR PRODUCTION THEREOF AND METHOD FOR PERCUTANEOUS ABSORPTION
  申请人：Cosmed Pharmaceutical Co., Ltd.

  公开号：EP2116266A1

  公开（公告）日：2009-11-11

  This invention is to provide a transdermal permeation preparation which includes a concentrated transdermal active ingredient laminate and exhibits high transdermal permeation effect; and a method for producing the preparation A transdermal permeation preparation which comprises a base material which is a hydrophilic macromolecule which can swell after absorbing the water and/or water-containing alcohol and comprises a transdermal active ingredient which is in a molecular weight higher than 1000 Dalton and can dissolve or suspend in water and/or water-containing alcohol laminated on the surface of the base material, ; and a method for producing the transdermal permeation preparation wherein the transdermal active ingredient of a molecular weigh higher than 1000 Dalton is dissolved or suspended in water and/or water-containing alcohol to form an aqueous solution or suspension and the said aqueous solution or suspension is coated on the surface of base materials which are hydrophilic macromolecules which can swell after absorbing the water or e water-containing alcohol as a result of absorption of the water or the water-containing alcohol in the base material, thereby forming a layer containing the transdermal active ingredient in a concentrated state on the surface of the base material.

  本发明旨在提供一种透皮渗透制剂，该制剂包括浓缩的透皮活性成分薄片，并具有较高的透皮渗透效果；以及生产该制剂的方法。 一种透皮渗透制剂，其包括基质材料，该基质材料为亲水性大分子，在吸收水和/或含水酒精后可膨胀，并包括透皮活性成分，该透皮活性成分的分子量大于1000道尔顿，可溶解或悬浮于水和/或含水酒精中，层叠在基质材料表面，；以及一种透皮渗透制剂的生产方法，其中将分子量大于 1000 道尔顿的透皮活性成分溶解或悬浮于水和/或含水醇中，形成水溶液或悬浮液，并将所述水溶液或悬浮液涂覆在基底材料表面，基底材料为亲水性大分子，在吸收水或含水醇后，基底材料中的水或含水醇会膨胀、从而在基底材料表面形成一层含有透皮活性成分的浓缩层。
• TRANSDERMAL IMMUNE PREPARATION, METHOD FOR PRODUCTION OF THE SAME, AND TRANSDERMAL IMMUNIZATION METHOD USING THE SAME
  申请人：Cosmed Pharmaceutical Co., Ltd.

  公开号：EP2116256A1

  公开（公告）日：2009-11-11

  This invention is concernced with transdermal immune preparations which can exhibit a high immunological activity without containing any adjuvant, methods for producing the preparation, and transdermal immunization methods using the preparation. The transdermal immune preparations can regulate the immune response by applying the preparation to an intact skin, and which comprises a base material and an antigen or artificial synthetic nucleic acid laminated on the surface of the base material; the methods for producing transdermal immune preparations which comprises putting drops of an aqueous solution or suspension prepared by dissolving or suspending an antigen in water or a water-containing alcohol on the surface of a base material in order for the water or the water-containing alcohol to be absorbed in the base material, thereby forming an layer containing the antigen in a concentrated state on the surface of the base material; and the transdermal immunization methods which is haracterized by applying the transdermal immune preparation to an intact skin to regulate the immune response.

  本发明涉及不含任何佐剂而能显示高免疫活性的透皮免疫制剂、制剂的生产方法和使用制剂的透皮免疫方法。 透皮免疫制剂可通过将制剂涂抹在完整的皮肤上调节免疫反应，它包括基底材料和层叠在基底材料表面的抗原或人工合成核酸；透皮免疫制剂的生产方法，包括将通过将抗原溶解或悬浮在水或含水酒精中制备的水溶液或悬浮液滴在基底材料表面，以使水或含水酒精被基底材料吸收，从而在基底材料表面形成一层含有浓缩状态抗原的层；以及透皮免疫方法，其特点是将透皮免疫制剂涂抹在完整的皮肤上以调节免疫反应。