2,2-Dimethylpropyl octanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-Dimethylpropyl octanoate
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.34
• InChiKey: LDYUQAGCEKANHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PRODRUG OF FLUORINE-CONTAINING AMINO ACID
  申请人：TAISHO PHARMACEUTICAL CO., LTD.

  公开号：US20150141669A1

  公开（公告）日：2015-05-21

  Provided are a fluorine-containing amino acid prodrug represented by general formula (I) that makes a fluorine-containing amino acid which is a group 2 metabotropic glutamate receptor agonist into a prodrug, or a pharmaceutically acceptable salt thereof. More specifically, provided is a prodrug that increases the in vivo exposure and enhances the oral absorbability and other mucosal absorbability of a parent compound that acts on group 2 metabotropic glutamate receptors as an agent for the treatment or prevention of diseases in which group 2 metabotropic glutamate receptors are said to be involved, such as: schizophrenia, anxiety disorder and its related diseases, depression, bipolar disorder, epilepsy, developmental disorders, sleep disorders, and other neuropsychiatric diseases; and drug dependence, cognitive disorders, Alzheimer's disease, Huntington's chorea, Parkinson's disease, movement disorders associated with muscular rigidity, cerebral ischemia, cerebral insufficiency, spinal cord disorders, cephalopathy, and other neurological diseases.

  提供了一种含氟氨基酸前药，其通式表示为(I)，可将作为2型代谢性谷氨酸受体激动剂的含氟氨基酸制成前药，或其药学上可接受的盐。更具体地，提供了一种前药，可增加在体暴露量并增强口服吸收和其他粘膜吸收，作为治疗或预防2型代谢性谷氨酸受体参与的疾病的药物，如：精神分裂症，焦虑症及其相关疾病，抑郁症，双相障碍，癫痫，发育障碍，睡眠障碍和其他神经精神疾病；以及药物依赖，认知障碍，阿尔茨海默病，亨廷顿病，帕金森病，与肌肉僵硬相关的运动障碍，脑缺血，脑血管不足，脊髓疾病，头痛和其他神经系统疾病。
• REVERSIBLY THERMOCHROMIC COMPOSITION
  申请人：Kabushiki Kaisha Pilot Corporation

  公开号：EP2772523A1

  公开（公告）日：2014-09-03

  [Object] To provide a reversibly thermochromic composition free from accidental discoloration by heat conducting from the opposite side writing surface or by self-heating due to quick writing; and also to provide a solid writing material and a writing ink composition comprising that composition. [Means to solve the problem] A reversibly thermochromic composition comprising a combination of: (a) a reversibly thermochromic component capable of being discolored or decolored by heat and (b) a component for controlling heat conducting to the reversibly thermochromic component; and also a solid writing material and a writing ink composition comprising that composition.

  [目的]提供一种可逆热致变色组合物，该组合物不会因反面书写面的热传导或快速书写导致的自热而意外变色；还提供一种固体书写材料和包含该组合物的书写墨水组合物。 [解决问题的方法] 一种可逆热致变色组合物，由以下物质组合而成：(a) 能够受热变色或脱色的可逆热致变色成分和 (b) 用于控制热量传导至可逆热致变色成分的成分；以及包含该成分的固体书写材料和书写墨水组合物。
• Tunable directional color transition compositions and methods of making and using the same
  申请人：Segan Industries, Inc.

  公开号：US10168307B1

  公开（公告）日：2019-01-01

  Color change compositions that transition from a first to second color state upon application of an applied stimulus are provided. Also provided are substrates having the compositions on a surface thereof, as well as methods of making and using the compositions.

  本发明提供了在施加外加刺激时可从第一种颜色状态过渡到第二种颜色状态的变色组合物。此外，还提供了在其表面具有这些组合物的基底，以及制作和使用这些组合物的方法。
• Compounds for reducing background color in color change compositions
  申请人：Segan Industries, Inc.

  公开号：US10570294B2

  公开（公告）日：2020-02-25

  Aspects of the invention include color change compositions having a color former and color developer composition that transitions from a first color state to a second color state upon application of an applied stimulus and an amount of a copolymer sufficient to eliminate background color of the color former and color developer composition during transition from the first color state to the second color state. Methods for preparing and devices employing the color change compositions of the invention are also described.

  本发明的各个方面包括变色组合物，该组合物具有在施加外加刺激时从第一颜色状态过渡到第二颜色状态的显色剂和足够量的共聚物，以便在从第一颜色状态过渡到第二颜色状态期间消除显色剂和显色剂组合物的背景色。此外，还描述了制备本发明变色组合物的方法和使用本发明变色组合物的装置。
• COMPOUNDS FOR REDUCING BACKGROUND COLOR IN COLOR CHANGE COMPOSITIONS
  申请人：Segan Industries, Inc.

  公开号：EP2969582B1

  公开（公告）日：2021-06-02