Nonyl 2-ethylhexanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Nonyl 2-ethylhexanoate
• 化学式: C₁₇H₃₄O₂
• 分子量: 270.5
• InChiKey: DPNHJKKWWDXLPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS<br/>[FR] NOUVEAUX LIPIDES ET FORMULATIONS NANOPARTICULAIRES LIPIDIQUES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：ACUITAS THERAPEUTICS INC

  公开号：WO2015199952A1

  公开（公告）日：2015-12-30

  Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

  提供具有以下结构的化合物：(I)或其药用盐、互变异构体或立体异构体，其中R1a、R1b、R2a、R2b、R3a、R3b、R4a、R4b、R5、R6、R7、R8、R9、L1、L2、a、b、c、d和e的定义如本文所述。还提供了将这些化合物用作脂质纳米粒子制剂的组分、包含这些化合物的组合物以及其使用和制备方法。
• NOVEL ESTERS, AND USE THEREOF
  申请人：Kawa Rolf

  公开号：US20120100197A1

  公开（公告）日：2012-04-26

  The invention relates to esters of general formula (I) R 1 —C(═O)—O—R 2 , wherein (1) R 1 represents a linear alkyl radical having 7 to 9 carbon atoms and R 2 represents a linear alkyl radical having 9 to 10 carbon atoms or (2) R 1 is a linear alkyl radical having 8 to 9 carbon atoms and R 2 is a linear alkyl radical having 8 carbon atoms, or (3) R 1 is a linear alkyl radical having 7 to 9 carbon atoms and R 2 is a linear alkyl radical having 7 carbon atoms, or (4) R 1 is an alkyl radical having 7 or 8 carbon atoms and R 2 is an alkyl radical having 9 carbon atoms where, if R 1 is a linear alkyl radical, R 2 is a branched alkyl radical, or, if R 1 is a branched alkyl radical, R 2 is a linear alkyl radical or (5) R 1 represents an alkyl radical having 8 carbon atoms and R 2 is an alkyl radical having 8 carbon atoms, where, if R 1 is a linear alkyl radical, R 2 is a branched alkyl radical, or, if R 1 is a branched alkyl radical, R 2 is a linear alkyl radical, or n-octyl isooctanoate, n-dec I isooctanoate, n-decyl isononanoate, isononyl n-decanoate, n-heptyl n-dodecanoate or isononyl isooctanoate.

  该发明涉及通式（I）R1—C（═O）—O—R2的酯，其中（1）R1代表具有7到9个碳原子的直链烷基基团，R2代表具有9到10个碳原子的直链烷基基团，或（2）R1是具有8到9个碳原子的直链烷基基团，R2是具有8个碳原子的直链烷基基团，或（3）R1是具有7到9个碳原子的直链烷基基团，R2是具有7个碳原子的直链烷基基团，或（4）R1是具有7或8个碳原子的烷基基团，R2是具有9个碳原子的烷基基团，如果R1是直链烷基基团，则R2是支链烷基基团，或者如果R1是支链烷基基团，则R2是直链烷基基团，或（5）R1代表具有8个碳原子的烷基基团，R2代表具有8个碳原子的烷基基团，如果R1是直链烷基基团，则R2是支链烷基基团，或者如果R1是支链烷基基团，则R2是直链烷基基团，或正辛基异辛酸酯，正十基异辛酸酯，正十基异壬酸酯，异壬基正癸酸酯，正庚基正十二酸酯或异壬基异辛酸酯。
• A method for improving the release of a cast concrete item from the mould by applying to the mould a mould release composition
  申请人：CASTROL A/S

  公开号：EP0328158A1

  公开（公告）日：1989-08-16

  The release of a moulded concrete body from the mould can be improved by applying to the mould an effective amount of a concrete release composition comprising one or more oily esters of aliphatic carboxylic acids with mono- or dihydric alcohols, with a melting point of at the most 35°C, the total number of carbon atoms in the esters being 8-46, in an amount of 26-100% by weight, calculated on the total composition, optionally in admixture with other additives such as mineral oils, vegetable oils, glycols, glycol ethers, alkanols, emulsifiers and/or water.

  在模具上涂抹有效量的混凝土脱模组合物，可改善模制混凝土体的脱模效果，该组合物由一种或多种脂肪族羧酸与一元醇或二元醇的油性酯组成，熔点不超过 35°C、酯中的碳原子总数为 8-46，重量百分比为 26-100%，以总成分计算，可与其他添加剂如矿物油、植物油、乙二醇、乙二醇醚、烷醇、乳化剂和/或水混合使用。
• LUBRICATING OIL FOR REFRIGERATOR, HYDRAULIC FLUID COMPOSITION FOR REFRIGERATOR AND METHOD FOR LUBRICATION OF REFRIGERATOR
  申请人：NEW JAPAN CHEMICAL CO.,LTD.

  公开号：EP1225213A1

  公开（公告）日：2002-07-24

  The invention provides a lubricating oil for refrigerators, comprising (a) at least one ester represented by the formula (1) wherein R1 is C1 to C18 straight-chain alkyl or C3 to C18 branched-chain alkyl; R2 is H, C1 to C18 straight-chain alkyl or C3 to C18 branched-chain alkyl; with the poviso that the total number of carbons contained in the alkyls represented by R1 and R2 is 2 to 18 and that when R2 is H, R1 is branched-chain alkyl; and R3 is C1 to C20 straight-chain alkyl, C3 to C20 branched-chain alkyl or C3 to C10 cycloalkyl, optionally in combination with (b) at least one member selected from the group consisting of fatty acid polyol esters, phthalic acid esters, alicyclic dicarboxylic acid esters, polyvinyl ethers, hydrocarbon oils and polyalkylene glycols; as well as a method for lubricating a refrigerator using such a lubricating oil, and a working fluid composition for refrigerators comprising (I) component (a) or components (a) and (b) and (II) a refrigerant.

  本发明提供了一种用于冰箱的润滑油，包括 (a) 至少一种由式 (1) 代表的酯类 其中 R1 是 C1 至 C18 直链烷基或 C3 至 C18 支链烷基；R2 是 H、C1 至 C18 直链烷基或 C3 至 C18 支链烷基；前提是 R1 和 R2 所代表的烷基所含的碳总数为 2 至 18，且当 R2 为 H 时，R1 为支链烷基；和 R3 是 C1 至 C20 直链烷基、C3 至 C20 支链烷基或 C3 至 C10 环烷基，可选择与 (b) 至少一种选自脂肪酸多元醇酯、邻苯二甲酸酯、脂环二羧酸酯、聚乙烯醚、烃油和聚烷基二 醇组成的组的成员结合使用；以及一种使用这种润滑油润滑冰箱的方法，和一种用于冰箱的工作液组合物，该组合物包括 (I) 成分 (a) 或成分 (a) 和 (b) 以及 (II) 制冷剂。
• Method for retarding the setting of mortar and concrete surfaces
  申请人：W.R. GRACE & CO.-CONN.

  公开号：EP1887053A1

  公开（公告）日：2008-02-13

  An exemplary method for set retarding the surface of a mortar or concrete material, comprising applying to the surface of a mortar or concrete, or to the inner surface of a mold for forming the mortar or concrete, a non-petroleum based hot melt coating composition which is heated to assume a flowable or sprayable form, and allowing the hot melt coating composition to cool to ambient temperature whereby the composition forms a solidified membrane, and thereafter removing the membrane using pressurized water. Preferably, the hot melt coating composition contains at least one agent operative to retard the setting of the mortar or concrete, and optional finely divided particulate materials, light-reflective pigments, or mixtures thereof.

  一种用于砂浆或混凝土材料表面凝固延缓的示例性方法，包括将非石油基热熔涂料组合物涂抹在砂浆或混凝土表面，或涂抹在用于形成砂浆或混凝土的模具内表面，该组合物经加热后呈可流动或可喷涂形式，并使热熔涂料组合物冷却至环境温度，从而使该组合物形成一层固化膜，然后使用加压水去除该膜。热熔涂料组合物最好含有至少一种可延缓灰泥或混凝土凝固的药剂，以及可选的细小颗粒材料、光反射颜料或其混合物。