Propionic acid, 2-isopropoxy-, methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Propionic acid, 2-isopropoxy-, methyl ester
• 英文别名: methyl 2-propan-2-yloxypropanoate
• 化学式: C₇H₁₄O₃
• 分子量: 146.18
• InChiKey: YVAHFGLAUJAYAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20070010489A1

  公开（公告）日：2007-01-11

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有HIV蛋白酶抑制剂性质的膦酸酯取代化合物，其具有作为治疗剂和其他工业用途的用途。该组合物抑制5型HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面具有治疗作用，以及在检测HIV蛋白酶方面的检测中有用。
• 4-PHENYLPYRANE-3,5-DIONES, 4-PHENYLTHIOPYRANE-3,5-DIONES AND 2-PHENYLCYCLOHEXANE-1,3,5-TRIONES AS HERBICIDES
  申请人：Muehlebach Michel

  公开号：US20100279872A1

  公开（公告）日：2010-11-04

  Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.

  Pyrandione、thiopyrandione和cyclohexanetrione化合物，适用于作为除草剂使用。
• AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1
  申请人：HOLCOMB Ryan C.

  公开号：US20120238540A1

  公开（公告）日：2012-09-20

  The invention relates to certain amino-pyrimidine compounds that inhibit IKK epsilon and/or TBK1, methods of making such compounds, pharmaceutical compositions comprising such compounds, and the use of these compounds in treating a variety of diseases and disorders.

  本发明涉及一些氨基嘧啶化合物，可抑制IKK epsilon和/或TBK1，制备这种化合物的方法，包含这种化合物的药物组合物，以及在治疗各种疾病和疾病失调中使用这些化合物的方法。
• AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON
  申请人：Alzheimer's Institute of America

  公开号：US20150352108A1

  公开（公告）日：2015-12-10

  The invention relates to certain amino-pyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).

  该发明涉及某些氨基嘧啶化合物，其抑制TBK1和/或IKK epsilon，因此可能在治疗炎症、癌症、感染性休克和/或原发性开角青光眼（POAG）方面找到应用。
• CARBOXYLIC ACID DERIVATIVE AND SALT THEREOF
  申请人：Eisai Co., Ltd.

  公开号：EP1380562A1

  公开（公告）日：2004-01-14

  The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein R1 represents a hydrogen atom, hydroxyl group, halogen, carboxyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents; L represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; M represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; T represents a single bond, or a C1-3 alkylene group, a C2-3 alkenylene group or a C2-3 alkynylene group, each of which may have one or more substituents; W represents a carboxyl group; - - - represents a single bond etc. ; X represents a single bond, oxygen atom, a group represented by -NRX1CQ1O- (wherein Q1 represents an oxygen atom or sulfur atom; and RX1 represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents), -OCQ1NRX1- (wherein Q1 and RX1 are as defined above), -CQ1NRx1O- (wherein Q1 and RX1 are as def ined above), ONRX1CQ1- (wherein Q1 and RX1 are as defined above), - Q2SO2- (wherein Q2 is an oxygen atom or -NRX10- (wherein RX10 represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents)) or -SO2Q2- (wherein Q2 is as defined above), (wherein, provided that RX2 and RX3, and/or RX4 and RX5 may together form a ring, Q3 and Q4 are the same as or different from each other and each represents an oxygen atom, (O)S(O) or NRX10 (wherein NRX10 is as defined above)); Y represents a 5- to 14-membered aromatic group etc., which may have one or more substituents and one or more hetero atoms; and the ring Z represents a 5-to 14-membered aromatic group which may have 0 to 4 substituents and one or more hetero atoms, and wherein part of the ring may be saturated.

  本发明提供了一种可用作胰岛素增敏剂的新型羧酸化合物、其盐或其水合物，以及包含该化合物作为活性成分的药物。也就是说，本发明提供了由下式代表的羧酸化合物、其盐、其酯或它们的水合物。 其中 R1 代表氢原子、羟基、卤素、羧基或 C1-6 烷基等、L 代表单键，或 C1-6 亚烷基、C2-6 亚烯基或 C2-6 亚炔基，其中每个基团可带有一个或多个取代基；M 代表单键，或 C1-6 亚烷基、C2-6 亚烯基或 C2-6 亚炔基，其中每个基团可有一个或多个取代基； T 代表单键，或 C1-3 亚烷基、C2-3 亚烯基或 C2-3 亚炔基，其中每个基团可有一个或多个取代基； W 代表羧基； - - - 代表单键等；X 代表单键、氧原子、由 -NRX1CQ1O- 代表的基团（其中 Q1 代表氧原子或硫原子；RX1 代表氢原子、甲酰基或 C1-6 烷基等）、其中每个取代基可有一个或多个）、-OCQ1NRX1-（其中 Q1 和 RX1 如上定义）、-CQ1NRx1O-（其中 Q1 和 RX1 如上定义）、ONRX1CQ1-（其中 Q1 和 RX1 如上定义）、-Q2SO2-（其中 Q2 是氧原子或-NRX10-（其中 RX10 代表氢原子、甲酰基或 C1-6 烷基等、其中每个基团可具有一个或多个取代基））或-SO2Q2-（其中 Q2 如上定义）、 (其中，只要 RX2 和 RX3，和/或 RX4 和 RX5 可共同形成一个环，Q3 和 Q4 彼此相同或不同，且各自代表氧原子、（O）S（O）或 NRX10（其中 NRX10 如上定义））；Y 代表 5 至 14 元芳香基团等、环 Z 代表 5 至 14 元芳香基团，可具有 0 至 4 个取代基和一个或多个杂原子，其中部分环可为饱和环。