Isopentanoylleucin | 91280-21-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Isopentanoylleucin
• 英文别名: Isovaleryl-DL-leucin；N-isovalerylleucine；N-Isovaleryl-dl-leucine；4-methyl-2-(3-methylbutanoylamino)pentanoic acid
• CAS: 91280-21-6
• 化学式: C₁₁H₂₁NO₃
• mdl: MFCD09045987
• 分子量: 215.293
• InChiKey: FMMALDPKAFKRAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.818
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] AMINO ACID DEPLETION AGENTS AS ANTIPROLIFERATIVE AGENTS<br/>[FR] AGENTS D'APPAUVRISSEMENT EN ACIDES AMINÉS EN GUISE D'AGENTS ANTIPROLIFÉRATIFS
  申请人：UNIV CENTRAL FLORIDA RES FOUND INC

  公开号：WO2020047361A1

  公开（公告）日：2020-03-05

  Novel compounds are described which decrease the intracellular levels of leucine and methionine. Treatment with these amino acid depletion agents affects many metabolic and life processes which rely upon methionine, leucine and their derivatives. Methionine depletion not only inhibits protein synthesis, but also polyamine biosynthesis and significantly reduces intracellular pools of the native polyamines, spermidine and spermine. Since methionine restriction has been shown to mimic caloric restriction in life extension studies across multiple species, these compounds are also expected to extend lifespan by limiting methionine supply.

  描述了几种新的化合物，这些化合物能够降低细胞内亮氨酸和蛋氨酸的水平。使用这些氨基酸剥夺剂影响许多依赖蛋氨酸、亮氨酸及其衍生物的代谢和生命过程。蛋氨酸剥夺不仅抑制蛋白质合成，还抑制聚胺生物合成，并显著减少细胞内天然聚胺，即亚精胺和精胺的池。由于蛋氨酸限制在多个物种的生命延长研究中已被证明可以模仿卡路里限制，因此预计这些化合物通过限制蛋氨酸供应也能延长寿命。
• Substituted Morphinans and the Use Thereof
  申请人：Purdue Pharma L.P.

  公开号：US20150175571A1

  公开（公告）日：2015-06-25

  The application is directed to compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3 , R 4a , and R 4b are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.

  该申请涉及I式化合物及其药学上可接受的盐和溶剂化合物，其中R1、R2、R3、R4a和R4b如规范中所述。本发明还涉及使用I式化合物治疗对一种或多种阿片受体调节有响应的疾病，或用作合成中间体。本发明的某些化合物特别适用于治疗疼痛。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0226304B1

  公开（公告）日：1991-08-28
• AMINO ACID DEPLETION AGENTS AS ANTIPROLIFERATIVE AGENTS
  申请人：University of Central Florida Research Foundation, Inc.

  公开号：EP3843779A1

  公开（公告）日：2021-07-07
• SUBSTITUTED ANIONIC COMPOUNDS CONSISTING OF A BACKBONE MADE UP OF A DISCRETE NUMBER OF SACCHARIDE UNITS
  申请人：ADOCIA

  公开号：US20140187499A1

  公开（公告）日：2014-07-03

  The invention relates to substituted anionic compounds consisting of a backbone made up of a discrete number u of between 1 and 8 (1≦u≦8) of identical or different saccharide units, linked via identical or different glycosidic bonds, said saccharide units being chosen from the group consisting of pentoses, hexoses, uronic acids, N-acetylhexosamines in cyclic form or in open reduced form, which are randomly substituted. It also relates to the process for the preparation thereof and to the pharmaceutical compositions comprising same.

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