N-(2-Nitrophenyl)-2-(2-thienyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-Nitrophenyl)-2-(2-thienyl)acetamide
• 英文别名: N-(2-nitrophenyl)-2-thiophen-2-ylacetamide
• 化学式: C₁₂H₁₀N₂O₃S
• mdl: MFCD01604523
• 分子量: 262.289
• InChiKey: ZWTGULSQKWTTGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-噻吩乙酰氯 、 2-硝基苯胺 以 四氢呋喃 为溶剂， 以100%的产率得到N-(2-Nitrophenyl)-2-(2-thienyl)acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents

  摘要：

  The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mu g/mL. The compounds 2, 3, 7, 8,11, 12, 15,16, and 20 exhibited activity between 25 and 100 mu g/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.096