2-tert-Butyl-pyrroline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 2-tert-Butyl-pyrroline
• 英文别名: 5-tert-butyl-2,3-dihydro-1H-pyrrole
• 化学式: C₈H₁₅N
• 分子量: 125.21
• InChiKey: YPNGFYOHBPYEKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Topical Compositions Comprising Non-Proteogenic Amino Acids and Methods of Treating Skin
  申请人：Ptchelintsev Dmitri S.

  公开号：US20100261769A1

  公开（公告）日：2010-10-14

  Cosmetic compositions comprising non-natural, non-proteogenic amino acids and methods of using such compositions to impart antiaging benefits to the skin are disclosed. The non-natural, non-proteogenic amino acids are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging, and in particular, are enhancers of LOXL-1.
• Paxillin Stimulating Compositions and Cosmetic Uses Thereof
  申请人：ZHENG Qian

  公开号：US20110151029A1

  公开（公告）日：2011-06-23

  Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.
• TYROSINASE INHIBITORS
  申请人：AVON PRODUCTS, INC.

  公开号：US20150164758A1

  公开（公告）日：2015-06-18

  The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.
• TOPICAL COMPOSITIONS AND METHODS FOR SKIN LIGHTENING
  申请人：AVON PRODUCTS INC.

  公开号：US20160263006A1

  公开（公告）日：2016-09-15

  Embodiments of the invention are generally directed to compositions useful for reducing pigmentation in the skin. The composition may further include other depigmenting agents such as nicotinamide and its melanasome transfer-inhibiting derivatives, 3,3′-thiodipropanoic acid and its tyrosinase-inhibiting derivatives, or resorcinol and its tyrosinase-inhibiting derivatives, in a topically acceptable vehicle.
• K-RAS MUTATIONS AND ANTAGONISTS
  申请人：The Trustees of the Stevens Institute of Technolog

  公开号：US20190134056A1

  公开（公告）日：2019-05-09

  The present application relates to K-Ras mutations, to polynucleotides encoding mutant K-Ras polypeptides, and to methods of identifying small molecule antagonists using K-Ras mutations. The present application also relates to K-Ras small molecule antagonists and use thereof in the treatment of tumors.