(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl octadec-9-enoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl octadec-9-enoate
• 化学式: C₂₄H₄₄O₄
• 分子量: 396.6
• InChiKey: LEEQPXMGHNSQNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  28
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• TRIACYLGLYCEROL OLIGOMERS
  申请人：Trent University

  公开号：US20150321992A1

  公开（公告）日：2015-11-12

  This application relates to triacylglycerol oligomers derived from the metathesis of natural oils. These oligomers are structure controlled dimers and quatrimers, and the effect of saturation, molecular size, and positional isomerization are also described herein.

  这个应用涉及从天然油脂的交换反应中得到的三酰甘油寡聚体。这些寡聚体是结构受控的二聚体和四聚体，本文还描述了饱和度、分子大小和位置异构化的影响。
• Compounds and compositions comprising such compounds for the prevention or treatment of dyslipidaemias
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US10231985B2

  公开（公告）日：2019-03-19

  The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a subject, said dyslipidemia typically being linked to the excess presence in the biological membranes, including in the biological membranes of non-adipocyte cells, of fatty acids, in particular of saturated long-chain fatty acids, and/or of sterols. The invention also relates to compositions, in particular pharmaceutical compositions and food supplements or complements, comprising such compounds, and to the uses thereof for preventing and/or treating dyslipidemia. The compounds and compositions according to the invention can in particular be advantageously used for preventing and/or treating a pathological condition selected from metabolic syndrome and/or a symptom or abnormality characteristic of metabolic syndrome, preferably for preventing or treating type 2 diabetes mellitus or hepatic steatosis.

  本发明涉及医学领域。所述血脂异常通常与生物膜（包括非脂肪细胞的生物膜）中脂肪酸（尤其是饱和长链脂肪酸）和/或甾醇的过量存在有关。本发明还涉及包含此类化合物的组合物，特别是药物组合物和食品补充剂或补品，以及其在预防和/或治疗血脂异常方面的用途。根据本发明的化合物和组合物尤其可有利地用于预防和/或治疗选自代谢综合征和/或代谢综合征特征性症状或异常的病理状况，最好用于预防或治疗 2 型糖尿病或肝脂肪变性。
• COMPOSES ET COMPOSITIONS COMPRENANT DE TELS COMPOSES POUR LA PRÉVENTION OU LE TRAITEMENT DES DYSLIPIDÉMIES
  申请人：Centre National de la Recherche Scientifique

  公开号：EP3065733A1

  公开（公告）日：2016-09-14
• COMPOSES, COMPOSITIONS ET UTILISATIONS CORRESPONDANTES, POUR LA PREVENTION ET/OU LE TRAITEMENT DES DYSLIPIDEMIES
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP3065732A1

  公开（公告）日：2016-09-14
• COMPOUNDS AND COMPOSITIONS COMPRISING SUCH COMPOUNDS FOR THE PREVENTION OR TREATMENT OF DYSLIPIDAEMIAS
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20160256429A1

  公开（公告）日：2016-09-08

  The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a subject, said dyslipidemia typically being linked to the excess presence in the biological membranes, including in the biological membranes of non-adipocyte cells, of fatty acids, in particular of saturated long-chain fatty acids, and/or of sterols. The invention also relates to compositions, in particular pharmaceutical compositions and food supplements or complements, comprising such compounds, and to the uses thereof for preventing and/or treating dyslipidemia. The compounds and compositions according to the invention can in particular be advantageously used for preventing and/or treating a pathological condition selected from metabolic syndrome and/or a symptom or abnormality characteristic of metabolic syndrome, preferably for preventing or treating type 2 diabetes mellitus or hepatic steatosis.