2-Amino-N-[2-(1H-indol-3-yl)-1-methyl-ethyl]-acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-N-[2-(1H-indol-3-yl)-1-methyl-ethyl]-acetamide
• 英文别名: 2-amino-N-[1-(1H-indol-3-yl)propan-2-yl]acetamide
• 化学式: C₁₃H₁₇N₃O
• 分子量: 231.29
• InChiKey: SFTSSVCRTXAUQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  70.9
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• COMPOUNDS FOR REDUCING CELLULAR MELANIN CONTENT
  申请人：Unilever N.V.

  公开号：EP3509566B1

  公开（公告）日：2020-11-04
• [EN] COMPOUNDS FOR REDUCING CELLULAR MELANIN CONTENT<br/>[FR] COMPOSÉS POUR RÉDUIRE LA TENEUR EN MÉLANINE CELLULAIRE
  申请人：UNILEVER NV

  公开号：WO2018046243A1

  公开（公告）日：2018-03-15

  The present invention relates to molecules capable of reducing cellular melanin content; in particular to reducing melanin content for applications in fields such as skin lightening. There is a continuing need for new cosmetic skin lightening agents, with improved overall effectiveness. It is therefore an object of the present invention to provide a compound that acts as a melanin content reducer. It is found that specific indolyl compounds can reduce the melanin content in the melanocytes. Disclosed is use of a compound of formula (I) or a salt thereof, for reducing cellular melanin content of human skin, where, (i) R is: (a) - (CH2)n - A, where n = 1 to 6 and A is -OH or -NH2; or b) - O-(CH2)n - X, where n = 1 to 5 and X is a halogen; (ii) R2 is -H, alkyl, n-hexyl, aryl, alkoxy or aryloxy group; and, (iii) R3 is -H, alkyl, aryl, alkoxy or aryloxy group.