4-Thiaheptane, 2,6-dihydroxy-1,7-diphenoxy-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-Thiaheptane, 2,6-dihydroxy-1,7-diphenoxy-
• 英文别名: 1-(2-hydroxy-3-phenoxypropyl)sulfanyl-3-phenoxypropan-2-ol
• 化学式: C₁₈H₂₂O₄S
• 分子量: 334.436
• InChiKey: YETNNBRINXNIGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯基缩水甘油醚 在 sodium sulfide 、 poly[N-(2-aminoethyl)acrylamido]trimethylammonium chloride 作用下， 以 乙腈 为溶剂， 反应 1.1h， 以91%的产率得到4-Thiaheptane, 2,6-dihydroxy-1,7-diphenoxy-
  参考文献：
  名称：

  使用季铵化氨基官能化交联聚丙烯酰胺作为新型聚合物相转移催化剂通过环氧化物裂解合成 β-二羟基硫化物

  摘要：

  聚[N-(2-氨基乙基)丙烯酰胺基]三甲基卤化铵树脂是一种新型固液相转移催化剂。这种季铵化聚丙烯酰胺通过 Na 2 S 催化环氧化物的区域选择性开环，在温和条件下以高收率获得双[β-羟基-烷基]硫化物。

  DOI：

  10.1080/104265090902651

文献信息

• Bis-(1-chlor-3-phenoxy-prop-2-yl)-sulfane - Nucleophile Substitution und Regiochemie, Diastereomerentrennung und -zuordnung. Synthese diastereomerenreiner Trithiacyclen
  作者：J. Heinicke、Th. Ristau、S. Jelonek、M. M�hlst�dt

  DOI：10.1002/prac.19963380165

  日期：——

  The title compounds 1 were substituted by a series of O-, N- and S-nucleophiles (H(2)0 solvolysis, AgOAc, NaN3, KSCN, NaSPh, thiourea). A strong tendency to beta-elimination of HCl depending on the kind of the attacking nucleophile was found. In most cases no regioisomerization could be detected in the isolated products of the nucleophilic displacement. Best results were obtained with sulfur nucleophiles. The separation of the diastereomeric mixture of the p-kresyl derivative 1b into the individual diastereomers 1bA and 1bB in a preparative scale was achieved. These 3-thia1,5-dichlorides and several products of substitution could be assigned to the meso- or (+/-)-form by examination of the stereochemistry and symmetry of the corresponding sulfoxides.The 1,5-dimercapto derivatives 8 are convenient as structural units for the synthesis of diastereomerically pure cis- or trans-disubstituted trithiacycles e.g. 15bA, 15bB. The (+/-)-form of the 4,6-disubstituted 2,5,8-trithia[9]-(2,6)-pyridinophane 16bA was characterized by X-ray crystal structure determination.
• Simple and highly efficient catalyst- and waste-free ring opening of epoxides with Na2S in water
  作者：Najmedin Azizi、Elham Akbari、Frough Ebrahimi、Mohammad R. Saidi

  DOI：10.1007/s00706-010-0261-0

  日期：2010.3

  Water was found to be a highly efficient and green catalyst and solvent for ring-opening reaction of epoxides with Na2S at room temperature to give substituted bis(hydroxyethyl)thioethers in high yields.