1,2,3,4-Tetrahydroisochinolin-2-propionamid | 35729-62-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2,3,4-Tetrahydroisochinolin-2-propionamid
• 英文别名: 2-<2-Carbamoyl-ethyl>-1.2.3.4-tetrahydro-isochinolin；3-(3,4-dihydro-1H-isoquinolin-2-yl)-propionamide；1,2,3,4-Tetrahydroisoquinoline-2-propionamide；3-(3,4-dihydro-1H-isoquinolin-2-yl)propanamide
• CAS: 35729-62-5
• 化学式: C₁₂H₁₆N₂O
• mdl: MFCD11939312
• 分子量: 204.272
• InChiKey: FHIGOVYFZMOEBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 5-HT7 receptor ligands
  申请人：Torrens Jover Antoni

  公开号：US20060040977A1

  公开（公告）日：2006-02-23

  The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

  本发明涉及对5-HT7受体具有药理活性的化合物，更具体地涉及一些四氢异喹啉丙基磺酰胺化合物，以及制备这些化合物的方法，包括它们的药物组合物，以及它们用于治疗和/或预防5-HT参与的疾病，如中枢神经系统障碍的用途。
• BIS-NAPHTHALIMIDES CONTAINING AMIDE AND THIOAMIDE LINKERS AS ANTICANCER AGENTS
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：EP0577745A1

  公开（公告）日：1994-01-12
• NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS
  申请人：VM Discovery, Inc.

  公开号：EP2073799A2

  公开（公告）日：2009-07-01
• 5-ht7 receptor antagonists
  申请人：Torrens Jover Antoni

  公开号：US20090088450A1

  公开（公告）日：2009-04-02

  The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
• US8586619B2
  申请人：——

  公开号：US8586619B2

  公开（公告）日：2013-11-19