1-[(3,4-Dimethoxyphenyl)sulfonyl]proline

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[(3,4-Dimethoxyphenyl)sulfonyl]proline
• 英文别名: 1-(3,4-dimethoxyphenyl)sulfonylpyrrolidine-2-carboxylic acid
• 化学式: C₁₃H₁₇NO₆S
• 分子量: 315.34
• InChiKey: KXBVANCVBWUHCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PROLINE SULFONAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Boss Christoph

  公开号：US20130150424A1

  公开（公告）日：2013-06-13

  The present invention relates to (S)-proline sulfonamide compounds of formula (I) wherein R 1 and R 2 are as described in the description, or pharmaceutically acceptable salts thereof, for use in the prevention or treatment of diseases or disorders related to the orexin system. The present invention also relates to the use of (S)-proline sulfonamide compounds of formula (II) as pharmaceuticals, to pharmaceutical compositions comprising compounds of formula (II), and especially their use in the prevention or treatment of diseases or disorders related to the orexin system.

  本发明涉及公式（I）中的（S）-脯氨酸磺酰胺化合物，其中R1和R2如说明书中所述，或其药学上可接受的盐，用于预防或治疗与促进素系统相关的疾病或障碍。本发明还涉及使用公式（II）中的（S）-脯氨酸磺酰胺化合物作为药物，制备含有公式（II）化合物的药物组合物，特别是它们在预防或治疗与促进素系统相关的疾病或障碍方面的使用。
• US8895606B2
  申请人：——

  公开号：US8895606B2

  公开（公告）日：2014-11-25
• US9000029B2
  申请人：——

  公开号：US9000029B2

  公开（公告）日：2015-04-07
• US9211279B2
  申请人：——

  公开号：US9211279B2

  公开（公告）日：2015-12-15
• [EN] PROLINE SULFONAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS DE PROLINE SULFONAMIDE COMME ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012025877A1

  公开（公告）日：2012-03-01

  The present invention relates to (S)-proline sulfonamide compounds of formula (I), wherein R1 and R2 are as described in the description, or pharmaceutically acceptable salts thereof, for use in the prevention or treatment of diseases or disorders related to the orexin system. The present invention also relates to the use of (S)-proline sulfonamide compounds of formula (II) as pharmaceuticals, to pharmaceutical compositions comprising compounds of formula (II), and especially their use in the prevention or treatment of diseases or disorders related to the orexin system.