{Acetyl-[(3-nitro-benzoylamino)-methyl]-amino}-acetic acid ethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: {Acetyl-[(3-nitro-benzoylamino)-methyl]-amino}-acetic acid ethyl ester
• 英文别名: N-Acetyl-N-[(3-nitrobenzamido)methyl]glycine ethyl ester；ethyl 2-[acetyl-[[(3-nitrobenzoyl)amino]methyl]amino]acetate
• 化学式: C₁₄H₁₇N₃O₆
• 分子量: 323.305
• InChiKey: UMPSRAZGMNERSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  122
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {Acetyl-[(3-nitro-benzoylamino)-methyl]-amino}-acetic acid ethyl ester 在 sodium hydroxide 作用下， 以 水 为溶剂， 以58%的产率得到{Acetyl-[(3-nitro-benzoylamino)-methyl]-amino}-acetic acid
  参考文献：
  名称：

  Chemical properties ofN-(amidomethy)- andN-(imidomethyl)glycine derivatives 2. Reactions at alkoxycarbonyl and carboxyl groups

  摘要：

  N-(Aroylaminomethyl)glycine amides were synthesized by reactions of N-(aroylnminomethyl)glycine esters with ammonia. Alkaline hydrolysis of N-(amidomethyl)glycine, N-(imidomethyl)glycine, and N-(amidomethyl)phenylalanine esters afforded the corresponding N-(amidomethyl)-alpha-amino acids. Reactions of the last-mentioned compounds with ethyl esters of glycine, alanine, and phenylalanine in the presence of dicyclohexylcarbodiimide yielded dipeptides containing N-amidomethyl substituents.

  DOI：

  10.1007/bf01431807

文献信息

• Chemical properties ofN-(amidomethy)- andN-(imidomethyl)glycine derivatives 2. Reactions at alkoxycarbonyl and carboxyl groups
  作者：S. G. Zlotin、I. V. Sharova、O. A. Luk'yanov

  DOI：10.1007/bf01431807

  日期：1996.7

  N-(Aroylaminomethyl)glycine amides were synthesized by reactions of N-(aroylnminomethyl)glycine esters with ammonia. Alkaline hydrolysis of N-(amidomethyl)glycine, N-(imidomethyl)glycine, and N-(amidomethyl)phenylalanine esters afforded the corresponding N-(amidomethyl)-alpha-amino acids. Reactions of the last-mentioned compounds with ethyl esters of glycine, alanine, and phenylalanine in the presence of dicyclohexylcarbodiimide yielded dipeptides containing N-amidomethyl substituents.