glycyl-glutamine | 115588-14-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glycyl-glutamine
• 英文别名: 5-amino-2-[(2-azaniumylacetyl)amino]-5-oxopentanoate
• CAS: 115588-14-2
• 化学式: C₇H₁₃N₃O₄
• 分子量: 203.198
• InChiKey: PNMUAGGSDZXTHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 、 水 作用下， 生成 glycyl-glutamine
  参考文献：
  名称：

  Leach; Lindley, Australian Journal of Chemistry, 1954, vol. 7, p. 173,178

  摘要：

  DOI：

文献信息

• Process for preparing a 3-hydroxy-3-methylbutyrate amino acid salt and method of use.
  申请人：——

  公开号：US20040176449A1

  公开（公告）日：2004-09-09

  This invention relates to a process for the synthesis and method of use of an effective amount of a 3-hydroxy-3-methylbutyrate (HMB) amino acid salt for the regulation athletic function in humans.

  这项发明涉及一种用于合成和使用3-羟基-3-甲基丁酸盐（HMB）氨基酸的有效量的过程和方法，用于调节人类运动功能。
• COMPOUNDS AND METHODS FOR DELIVERY OF PROSTACYCLIN ANALOGS
  申请人：United Therapeutics Corporation

  公开号：US20150259274A1

  公开（公告）日：2015-09-17

  This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.

  这项发明通常涉及前列环素配方及其在促进血管舒张、抑制血小板聚集和血栓形成、刺激溶栓、抑制细胞增殖（包括血管重塑）、提供细胞保护、预防动脉粥样硬化和诱导血管生成方面的用途方法。
• Process of producing ala-gln dipeptide
  申请人：Zhao Yufen

  公开号：US20050233977A1

  公开（公告）日：2005-10-20

  A synthesis method of alanyl-glutamine includes the steps of: The N-terminal protected alanine reacts with triphenylphosphine and hexachloroethane in organic solvent to form active ester, the active ester reacts with glutamine in a solution mixture containing organic solvent and aqueous solution of inorganic base, the resultant mixture is acidified with inorganic acid, and then the N-terminal protecting group is removed. In this method, the raw materials are cheap, the synthesis technique is simple, no disposals of separation and purification are needed, the product is easy to be separated and purified, the toxicities of all the reagents used in the course of production are minimal, it is advantageous to environment protection.

  一种丙氨酰谷氨酰胺的合成方法包括以下步骤：N-末端保护的丙氨酸在有机溶剂中与三苯基膦和六氯乙烷反应，形成活性酯，活性酯与谷氨酰胺在含有有机溶剂和无机碱水溶液的混合溶液中反应，得到的混合物用无机酸酸化，然后去除N-末端保护基。在这种方法中，原材料廉价，合成技术简单，无需分离和纯化处理，产品易于分离和纯化，生产过程中使用的所有试剂的毒性极小，有利于环境保护。
• Compositions to improve tic disorders
  申请人：Ozeki Makoto

  公开号：US20060217321A1

  公开（公告）日：2006-09-28

  Tic disorders can be improved by administering theanine, an amino acid that crosses the blood-brain barrier, or a dipeptide consisting of theanine and a different amino acid. In addition, these compositions can be added to foods and drinks or pharmaceuticals.

  滴状障碍可以通过给予茶氨酸改善，这是一种可以穿过血脑屏障的氨基酸，或者是由茶氨酸和另一种氨基酸组成的二肽。此外，这些组合物可以添加到食品和饮料或药品中。
• Compounds and methods for delivery of prostacyclin analogs
  申请人：Phares Ken

  公开号：US20050085540A1

  公开（公告）日：2005-04-21

  This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:

  本发明涉及前列环素类似物及其在促进血管扩张、抑制血小板聚集和血栓形成、刺激溶栓、抑制细胞增殖（包括血管重塑）、提供细胞保护、预防动脉粥样硬化和诱导血管生成方面的应用方法。一般而言，本发明的化合物和方法在口服给药时增加了曲前列素的口服生物利用度和循环浓度。本发明的化合物具有以下公式：