5,6,7,8-tetrahydro-anthracene-1,4-dione | 860586-08-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 5,6,7,8-tetrahydro-anthracene-1,4-dione
• 英文别名: 5,6,7,8-Tetrahydro-anthracen-1,4-dion；5,6,7,8-Tetrahydroanthracene-1,4-dione
• CAS: 860586-08-9
• 化学式: C₁₄H₁₂O₂
• 分子量: 212.248
• InChiKey: DWXLNXHEUIUNRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,6,7,8-tetrahydro-anthracene-1,4-dione 在 双氧水 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以40%的产率得到4,5,6,7-tetrahydroanthra[2,3-b]oxirene-2,9(1aH,9aH)-dione
  参考文献：
  名称：

  钌催化的中环氧二酮不对称加氢/转移加氢不对称化

  摘要：

  通过不对称还原去对称化的策略，合成了具有多个连续立体中心和官能团的手性顺式-环氧萘醌，具有优异的对映选择性（96-99％ee）和非对映选择性（8 / 1-15 / 1）。根据实验结果，提出了一种不对称加氢/转移加氢的联合机理。

  DOI：

  10.1021/acs.orglett.6b01073
• 作为产物：
  描述：

  5,6,7,8-tetrahydro-anthracene-1,4-diol 在 盐酸 、 乙醇 、 三氯化铁 作用下， 生成 5,6,7,8-tetrahydro-anthracene-1,4-dione
  参考文献：
  名称：

  Treatment of canine adult-onset demodicosis

  摘要：

  DOI：

  10.1111/j.1751-0813.2000.tb11742.x

文献信息

• Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases
  作者：Shugeng Cao、Brian T. Murphy、Caleb Foster、John S. Lazo、David G.I. Kingston

  DOI：10.1016/j.bmc.2008.10.090

  日期：2009.3

  Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular are enzymes overexpressed in human cancer cells, and they represent potential molecular targets for novel cancer chemotherapeutic treatments. A number of analogs exhibited significant inhibitory activity against these enzymes, and the bioassay data in addition to structure-activity relationships of these compounds will be discussed. (C) 2008 Elsevier Ltd. All rights reserved.
• JPS59212444A
  申请人：——

  公开号：JPS59212444A

  公开（公告）日：1984-12-01
• Indoleamine 2,3-Dioxygenase (IDO) Inhibitors
  申请人：ANDERSEN Raymond J.

  公开号：US20090042868A1

  公开（公告）日：2009-02-12

  Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacterial/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure.
• US7799776B2
  申请人：——

  公开号：US7799776B2

  公开（公告）日：2010-09-21