2-Chloromuconic acid | 52050-02-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Chloromuconic acid
• 英文别名: (2Z,4E)-2-chlorohexa-2,4-dienedioic acid
• CAS: 52050-02-9
• 化学式: C₆H₅ClO₄
• 分子量: 176.55
• InChiKey: OZNNVVBQWHRHHH-TZFCGSKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Chloromuconic acid 生成 (2E)-2-(5-oxo-2(5H)-furanylidene)acetic acid
  参考文献：
  名称：

  ROJO, F.;PIEPER, D. H.;ENGESSER, K. -H.;KNACKMUSS, H. -J.;TIMMIS, K. N., SCIENCE, 238,(1987) N 4832, 1395-1398

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氯邻苯二酚 生成 2-Chloromuconic acid
  参考文献：
  名称：

  ROJO, F.;PIEPER, D. H.;ENGESSER, K. -H.;KNACKMUSS, H. -J.;TIMMIS, K. N., SCIENCE, 238,(1987) N 4832, 1395-1398

  摘要：

  DOI：

文献信息

• ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
  申请人：Weiner David P.

  公开号：US20110053245A1

  公开（公告）日：2011-03-03

  This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermerdiates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

  本发明涉及酶、编码该酶的多核苷酸、使用这种多核苷酸和多肽的方法，更具体地涉及具有异构酶活性的酶，例如旋光酶活性，例如氨基酸旋光酶活性、丙氨酸旋光酶活性和/或表观异构酶活性，以及/或在分子内催化原子的重排，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学不活性的混合物，催化底物对映异构体的互变，催化只有一个不对称中心的底物中的不对称碳原子周围的立体化学反转，催化具有多个不对称中心的底物中的不对称碳原子周围的构型立体化学反转，和/或催化氨基酸的旋光化。因此，本发明提供了酶、组成物、制药组成物的生产方法、制药中间体、抗生素、甜味剂、肽酶、肽激素、燃料和燃料添加剂组成物、食品和食品添加剂、饮料和饮料添加剂、饲料和饲料添加剂、药物和药物添加剂、膳食补充剂、纺织品、木材、纸浆和洗涤剂，其中包括本发明所述的多肽或多核苷酸。
• Plant transformation construct
  申请人：OCCIDENTAL CHEMICAL CORPORATION

  公开号：EP0404183A1

  公开（公告）日：1990-12-27

  Disclosed is a plant transformation construct comprising DNA having (1) a ring-opening gene that encodes an enzyme that can open an aromatic ring, (2) upstream of the ring-opening gene, a eukaryotic promoter, and (3) downstream of said ring-opening gene, a polyadenylic acid addition site. Also disclosed is a plasmid that contains the plant transformation construct and bacteria that contain the plasmid. A transgenic plant cell that contains, as part of its genome, the plant transformation construct is also disclosed, and a transgenic plant is grown from the transgenic plant cell. Also disclosed is a method of degrading aromatic compounds in soil by planting the transgenic plant in the soil.

  本发明公开了一种植物转化构建体，其 DNA 具有以下特征 (1) 开环基因，该基因编码一种能打开芳香环的酶、 (2) 开环基因上游的真核启动子，以及 (3) 开环基因下游的多聚腺苷酸添加位点。 还公开了含有植物转化构建体的质粒和含有该质粒的细菌。还公开了一种转基因植物细胞，作为其基因组的一部分，该细胞含有植物转化构建体，并由该转基因植物细胞培养出转基因植物。还公开了一种通过在土壤中种植转基因植物来降解土壤中芳香化合物的方法。
• Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
  申请人：Ceres Incorporated

  公开号：EP1033405A2

  公开（公告）日：2000-09-06

  The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3' termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. 0Arabidopsis DNA is used in the present experiment, but the procedure is a general one.

  本发明提供了构成植物基因组片段的 DNA 分子及其编码的多肽。这些 DNA 分子可作为启动子或蛋白质编码序列或 UTR 或 3'终止序列，用于指定细胞中的基因产物，也可用于控制染色体中基因的行为，控制基因的表达，或作为基因绘图、识别或分离相同或相关 DNA 片段、或识别特定生物个体、或对具有共同性状的生物群体进行聚类的工具。 本实验中使用的是拟南芥 DNA，但这是一个通用程序。
• DNA Sequences
  申请人：Ceres Incorporated

  公开号：EP1887081A2

  公开（公告）日：2008-02-13

  The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3' termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait.

  本发明提供了构成植物基因组片段的 DNA 分子及其编码的多肽。这些 DNA 分子可作为启动子或蛋白质编码序列或 UTR 或 3'终止序列，用于指定细胞中的基因产物，也可用于控制染色体中基因的行为，控制基因的表达，或作为基因绘图、识别或分离相同或相关 DNA 片段、或识别特定生物个体或具有共同性状的生物群体的工具。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。