2-Oxo-capronsaeure-amid | 89531-27-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Oxo-capronsaeure-amid
• 英文别名: Hexonamide；2-oxohexanamide
• CAS: 89531-27-1
• 化学式: C₆H₁₁NO₂
• mdl: MFCD19206406
• 分子量: 129.159
• InChiKey: MFOXCBPAYMJQPW-UHFFFAOYSA-N

物化性质

• 熔点：
  107 °C(Solv: ethanol (64-17-5))
• 沸点：
  121-122 °C(Press: 4 Torr)
• 密度：
  1.029±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-Carbamoyl-3-propyl-oxirane-2-carboxylic acid 在 水 作用下， 生成 2-Oxo-capronsaeure-amid
  参考文献：
  名称：

  Syntheses of α-Keto Amides and Acids from Ethyl Alkylidenecyanoacetates¹

  摘要：

  DOI：

  10.1021/jo01046a038

文献信息

• Derivatized ethylene alpha-olefin polymer useful as multifunctional viscosity index improver
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0440506A2

  公开（公告）日：1991-08-07

  The present invention is directed to an oil-soluble oleaginous composition additive comprising at least one terminally unsaturated ethylene alpha-olefin polymer of from above 20,000 to about 500,000 number average molecular weight substituted with mono- or dicarboxylic acid producing moieties (preferably dicarboxylic acid or anhydride moieties), wherein the terminal unsaturation comprises terminal ethenylidene unsaturation. The mono- and dicarboxylic acid or anhydride substituted polymers of this invention are useful per se as additives to oleaginous compositions such as lubricating oils, and can also be reacted with a nucleophilic reagent, such as amines, alcohols, amino alcohols and reactive metal compounds, to form products which are also useful oleaginous composition additives, e.g., as multifunctional viscosity index improvers.

  本发明涉及一种油溶性含油组合物添加剂，该添加剂包含至少一种被产生单羧酸或二羧酸的分子（最好是二羧酸或酸酐分子）取代的平均分子量在 20,000 以上至 500,000 左右的端基不饱和乙烯-α-烯烃聚合物，其中端基不饱和包括端基乙烯基不饱和。本发明的单羧酸和二羧酸或酸酐取代聚合物本身可用作润滑油等含油组合物的添加剂，也可与胺类、醇类、氨基醇类和活性金属化合物等亲核试剂反应，形成同样可用作含油组合物添加剂的产品，如多功能粘度指数改进剂。
• Difluoroketamide derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US10428108B2

  公开（公告）日：2019-10-01

  The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein, compositions including the compounds and methods of using the compounds.

  本发明提供了具有通式 (I) 的新型化合物 其中 R1、R2、R3、R4、R5、R6、R7、R8 和 R9 如本文所述，还提供了包括这些化合物的组合物和使用这些化合物的方法。
• Methods for producing optically active alpha-hydroxy amides
  申请人：Ishihara Kohji

  公开号：US20050202545A1

  公开（公告）日：2005-09-15

  An objective of the present invention is to provide efficient methods for producing (R)-2-chloromandelamide with high optical purity. Another objective of the present invention is to provide novel methods for producing α-ketoamide reductases that reduce 2-chlorobenzoyl formamide to (R)-2-chloromandelamide with high optical purity, using NADPH as the coenzyme. An enzyme exhibiting high stereoselectivity was purified from a number of Saccharomyces cerevisiae enzymes with 2-chlorobenzoyl formamide-reducing activity, and the biochemical properties of the purified enzyme were analyzed. The analysis of a partial internal amino acid sequence of the purified enzyme revealed that the enzyme may be encoded by the putative open reading frame (ORF) YDL124w reported in the genome analysis. YDL124w was cloned and expressed in E. coli , and was subsequently shown to encode the α-ketoamide reductase. It was found that these resulting transformants facilitated the production of (R)-2-chloromandelamide from 2-chlorobenzoyl formamide.

  本发明的一个目的是提供生产光学纯度高的(R)-2-氯扁桃酰胺的有效方法。本发明的另一个目的是提供生产α-酮酰胺还原酶的新方法，该还原酶以 NADPH 为辅酶，将 2-氯苯甲酰甲酰胺还原成高光学纯度的(R)-2-氯扁桃酰胺。 从一些酵母菌中纯化出了一种具有高立体选择性的酶。 酵母 分析了纯化酶的生化特性。对纯化酶部分内部氨基酸序列的分析表明，该酶可能由基因组分析中报告的假定开放阅读框（ORF）YDL124w编码。YDL124w 被克隆并在 大肠杆菌 随后证明其编码α-酮酰胺还原酶。研究发现，这些转化子有助于从 2-氯苯甲酰甲酰胺中生产 (R)-2-氯扁桃酰胺。
• Kashinskii, V. V.; Burba, A. A.; Zul'karnaev, R. I., Journal of general chemistry of the USSR, 1984, vol. 54, # 12, p. 2478 - 2480
  作者：Kashinskii, V. V.、Burba, A. A.、Zul'karnaev, R. I.、Lapkin, I. I.

  DOI：——

  日期：——
• KASHINSKIJ, V. N.;BURBA, A. A.;ZULKARNAEV, R. I.;LAPKIN, I. I., ZH. OBSHCH. XIMII, 1984, 54, N 12, 2767-2770
  作者：KASHINSKIJ, V. N.、BURBA, A. A.、ZULKARNAEV, R. I.、LAPKIN, I. I.

  DOI：——

  日期：——