Ala-Ala-Gly | 16422-07-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ala-Ala-Gly
• 英文别名: H-Ala-Ala-Gly-OH；2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]acetic acid
• CAS: 16422-07-4
• 化学式: C₈H₁₅N₃O₄
• mdl: MFCD00038690
• 分子量: 217.225
• InChiKey: RLMISHABBKUNFO-WHFBIAKZSA-N

物化性质

• 熔点：
  241-242 °C (decomp)
• 沸点：
  581.8±45.0 °C(Predicted)
• 密度：
  1.266±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ala-Ala-Gly 、 9-芴甲基-N-琥珀酰亚胺基碳酸酯 在 碳酸氢钠 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 2.0h， 以98%的产率得到(((9H-fluoren-9-yl)methoxy)carbonyl)-L-alanyl-L-alanylglycine
  参考文献：
  名称：

  Total Stepwise Solid-Phase Synthesis of Oligonucleotide-(3‘→N)-Peptide Conjugates

  摘要：

  An efficient total stepwise solid-phase synthesis of oligonucleotide-(3'-->N)-peptide conjugates is described that makes use of either a controlled pore glass support or macroporous polystyrene beads. Extending our previous homoserine linker approach, we prepared a range of conjugates containing one of four different cell or nuclear penetration peptides together with oligonucleotides containing 2'-deoxynucleoside or 2'-O-methylribonucleoside phosphodiesters, or gapmers containing 2'- deoxyphosphorothioates. The route also allows incorporation of a fluorescent label within the conjugate for cell uptake studies.

  DOI：

  10.1021/ol026502u
• 作为产物：
  描述：

  Boc-Ala-Gly-OMe 在 盐酸 、 sodium hydroxide 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 乙醚 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 Ala-Ala-Gly
  参考文献：
  名称：

  Sorup,P., Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1977, vol. 358, p. 99 - 104

  摘要：

  DOI：

文献信息

• Metal Complexes of Peptides. III. The Preparation and Properties of Diammine(oligopeptidato)cobalt(III) Complexes
  作者：Hiroshi Kawaguchi、Mari Ishii、Tomoharu Ama、Takaji Yasui

  DOI：10.1246/bcsj.55.3750

  日期：1982.12

  Complexes of the [Co(tripeptidato)(NH3)2] and NH4[Co(tetrapeptidato)(NH3)2] types (tripeptidato and tetrapeptidato denote the tri- and tetraanions of the coordinating peptides respectively) have been prepared and characterized by means of their electronic, 1H NMR, and circular dichroism (CD) spectral data. In the NH4[Co(tetrapeptidato) (NH3)2] complex, the pep tide coordinates to cobalt(III) as a quadridentate

  [Co(tripeptidato)(NH3)2] 和 NH4[Co(tetrapeptidato)(NH3)2] 类型的复合物（三肽和四肽分别表示配位肽的三阴离子和四阴离子）已被制备和表征它们的电子、1H NMR 和圆二色性 (CD) 光谱数据。在 NH4[Co(tetrapeptidato) (NH3)2] 复合物中，肽通过氨基和三个酰胺基团的氮与钴 (III) 作为四齿配体配位。已发现邻位 CD 光谱的可加性适用于一系列含有 L-丙氨酸和/或甘氨酸残基的三肽的复合物。这些三肽和四肽复合物在水中很容易发生水化反应，释放出氨分子。
• MUTANT PROTEIN HAVING THE PEPTIDE-SYNTHESIZING ACTIVITY
  申请人：ABE Isao

  公开号：US20070292916A1

  公开（公告）日：2007-12-20

  The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208

  本发明旨在提供一种优秀的肽合成蛋白质及高效生产肽的方法。在以下（I）和（II）所示的蛋白质的至少一种存在下，通过在胺组分和羧组分存在下反应合成肽。其中，（I）为突变蛋白质，其氨基酸序列包括来自于突变1至突变68、突变239至突变290和突变324至突变377的一个或多个突变；（II）为突变蛋白质，其氨基酸序列包括来自于L1至L335和M1至M642的一个或多个突变。
• Mutant protein having the peptide-synthesizing activity
  申请人：Abe Isao

  公开号：US20070190602A1

  公开（公告）日：2007-08-16

  The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208

  本发明旨在提供一种优异的合成肽蛋白质及高效生产肽的方法。在以下(I)和(II)所示的蛋白质的存在下，通过反应胺组分和羧基组分来合成肽。(I)突变蛋白质的氨基酸序列包括来自突变1到68和突变239到290以及SEQ ID NO:2的氨基酸序列中的突变324到377中的一个或多个突变。(II)突变蛋白质的氨基酸序列包括来自突变L1到L335和M1到M642和SEQ ID NO:208的氨基酸序列中的一个或多个突变。
• MUTANT PROTEIN HAVING PEPTIDE-PRODUCTION ACTIVITY
  申请人：Ajinomoto Co., Inc.

  公开号：EP1829968A1

  公开（公告）日：2007-09-05

  The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208

  本发明旨在提供一种优良的多肽合成蛋白和一种高效生产多肽的方法。该多肽是在至少一种如下(I)和(II)所示的蛋白质存在下，通过胺组分和羧基组分反应合成的。 (I)突变体蛋白质，其氨基酸序列包含 SEQ ID NO:2 的氨基酸序列中的突变 1 至 68、突变 239 至 290 和突变 324 至 377 中的一个或多个突变。 (II)突变体蛋白质，其氨基酸序列包含以下突变中的一个或多个突变 SEQ ID NO:208 的氨基酸序列中的 L1 至 L335 突变和 M1 至 M642 突变中的任一个或多个突变的突变体蛋白。
• 679. The synthesis of simple peptides from anhydro-N-carboxyamino-acids
  作者：J. Leggett Bailey

  DOI：10.1039/jr9500003461

  日期：——