H-Tyr-3,5-di-(4-OMe-Ph)-Gly-Gly-Phe-Leu-OH | 1043899-36-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Tyr-3,5-di-(4-OMe-Ph)-Gly-Gly-Phe-Leu-OH
• 英文别名: (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-[4-hydroxy-3,5-bis(4-methoxyphenyl)phenyl]propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
• CAS: 1043899-36-0
• 化学式: C₄₂H₄₉N₅O₉
• 分子量: 767.879
• InChiKey: TUAONTVWZROBLR-KVBYWJEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  56
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  218
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  (4-甲氧基苯基)三氟硼酸钾 、 H-3,5-diiodo-Tyr-Gly-Gly-Phe-Leu-OH 在 potassium phosphate 、 trisodium tris(3-sulfophenyl)phosphine 、 palladium diacetate 作用下， 以 水 为溶剂， 反应 24.0h， 生成 H-Tyr-3,5-di-(4-OMe-Ph)-Gly-Gly-Phe-Leu-OH
  参考文献：
  名称：

  Arylation of Phe and Tyr Side Chains of Unprotected Peptides by a Suzuki−Miyaura Reaction in Water

  摘要：

  An efficient arylation in water of tyrosine and phenylalanine side chains from unprotected iodopeptides is accomplished by using Suzuki-Miyaura cross-coupling processes. The method is compatible with the hydrophilic and thermolabile nature of biologically active peptides. Also of interest, the arylated tyrosine peptides can be accessed in one-pot mode starting from native peptides.

  DOI：

  10.1021/ol801009z

文献信息

• Arylation of Phe and Tyr Side Chains of Unprotected Peptides by a Suzuki−Miyaura Reaction in Water
  作者：Maria Vilaró、Gemma Arsequell、Gregorio Valencia、Alfredo Ballesteros、José Barluenga

  DOI：10.1021/ol801009z

  日期：2008.8.7

  An efficient arylation in water of tyrosine and phenylalanine side chains from unprotected iodopeptides is accomplished by using Suzuki-Miyaura cross-coupling processes. The method is compatible with the hydrophilic and thermolabile nature of biologically active peptides. Also of interest, the arylated tyrosine peptides can be accessed in one-pot mode starting from native peptides.