4,5α-epoxy-17-methyl-morphinane-3,8α-diol | 63782-89-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 4,5α-epoxy-17-methyl-morphinane-3,8α-diol
• 英文别名: 4,5α-Epoxy-17-methyl-morphinan-3,8α-diol；Morphinan-3,8-alpha-diol, 4,5-alpha-epoxy-17-methyl-；(4R,4aR,5R,7aS,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-5,9-diol
• CAS: 63782-89-8
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.359
• InChiKey: UZBOXKCKSVVZGQ-BGXWKIPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] METHODS FOR PREVENTING AND REVERSING OPIOID ANALGESIC TOLERANCE IN SUBJECTS WITH CHRONIC PAIN<br/>[FR] PROCÉDÉS DE PRÉVENTION ET D'INVERSION DE LA TOLÉRANCE AUX ANALGÉSIQUES OPIOÏDES CHEZ DES SUJETS ATTEINTS DE DOULEUR CHRONIQUE
  申请人：THE REASEARCH FOUND FOR SUNY

  公开号：WO2021158317A1

  公开（公告）日：2021-08-12

  The current disclosure provides methods for treating chronic pain. The present methods reduce opioid analgesic/antiallodynic tolerance in a subject with chronic pain and prevent the development of opioid analgesic/antiallodynic tolerance. More specifically, the inventive methods include the administration of a caveolin-1 scaffolding domain competing polypeptide (CSD) and/or a non-receptor tyrosine kinase (c-Src) inhibitor to reduce opioid analgesic/antiallodynic tolerance as well as prevent the onset of opioid analgesic/antiallodynic tolerance in a subject with chronic pain.