2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-ethoxyphenyl)-6-methylpyrimidin-4-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-ethoxyphenyl)-6-methylpyrimidin-4-amine
• 英文别名: 2-(3,5-dimethylpyrazol-1-yl)-N-(4-ethoxyphenyl)-6-methylpyrimidin-4-amine
• 化学式: C₁₈H₂₁N₅O
• 分子量: 323.4
• InChiKey: XKJYQGQMUPMJPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  64.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pyrazolyl-Pyrimidines as Potassium Channel Modulating Agents and Their Medical Use
  申请人：Eriksen Birgitte L.

  公开号：US20090036475A1

  公开（公告）日：2009-02-05

  This invention relates to novel potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular respiratory diseases, epilepsy, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, immune suppression or pain.

  这项发明涉及新型钾通道调节剂，以及它们在制备药物组合物中的应用。此外，该发明针对用于治疗或缓解与钾通道活性相关的疾病或障碍的药物组合物，特别是呼吸道疾病、癫痫、抽搐、血管痉挛、冠状动脉痉挛、肾功能紊乱、多囊肾病、膀胱痉挛、尿失禁、膀胱排出道梗阻、肠易激综合征、胃肠功能紊乱、分泌性腹泻、缺血、脑缺血、缺血性心脏病、心绞痛、冠心病、创伤性脑损伤、精神病、精神分裂症、焦虑、抑郁症、痴呆、记忆和注意力缺陷、阿尔茨海默病、痛经、嗜睡症、雷诺氏病、间歇性跛行、干燥综合征、偏头痛、心律失常、高血压、缺席性癫痫发作、肌肉肌无力症、干燥综合症、2型糖尿病、胰岛素高血症、早产、秃头、癌症、免疫抑制或疼痛。