benzo[b]naphtho[2,3-d]furan-6-carbaldehyde | 103962-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: benzo[b]naphtho[2,3-d]furan-6-carbaldehyde
• 英文别名: Benzo[b]naphtho[2,3-d]furan-6-carbaldehyde；naphtho[2,3-b][1]benzofuran-6-carbaldehyde
• CAS: 103962-86-3
• 化学式: C₁₇H₁₀O₂
• 分子量: 246.265
• InChiKey: NLSPEVYSBFOMPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzo[b]naphtho[2,3-d]furan-6-carbaldehyde 在 potassium permanganate 作用下， 生成 benzo[b]naphtho[2,3-d]furan-6-carboxylic acid
  参考文献：
  名称：

  Chatterjea, Journal of the Indian Chemical Society, 1957, vol. 34, p. 347,354

  摘要：

  DOI：
• 作为产物：
  描述：

  苯并[b]萘并[2,3-d]呋喃 以58%的产率得到
  参考文献：
  名称：

  BAIR, KENNETH W.

  摘要：

  DOI：

文献信息

• Phenanthro[2,3-6]thiophene derivatives, pharmaceutical compositions and
  申请人：Burroughs Wellcome Co.

  公开号：US04910218A1

  公开（公告）日：1990-03-20

  The present invention relates to anti tumor compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tetracyclic aromatic ring system comprised of 5-membered and 6-membered rings and contains at least one heteroatom and 3 aromatic rings and a total of no more than 18 ring atoms, or a substituted derivative thereof; the heteroatom is preferably oxygen, sulfur or nitrogen; when it is nitrogen this is substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

  该发明涉及式（I）ArCH.sub.2 R.sup.1（I）的抗肿瘤化合物或其单甲基或单乙基醚（式（I）的化合物包括这些醚，总共不超过29个碳原子）；醚，酯；酸盐；其中Ar是由5-和6-成员环组成的融合四环芳香环系统，含有至少一个杂原子和3个芳香环，总共不超过18个环原子，或其取代衍生物；杂原子优选是氧、硫或氮；当它是氮时，它被氢、甲基或乙基取代；R.sup.1含有不超过八个碳原子，是一个基团##STR1##其中m为0或1；R.sup.5为氢；R.sup.6和R.sup.7相同或不同，每个是氢或C.sub.1-5烷基，可选择地被羟基取代；R.sup.8和R.sup.9相同或不同，每个是氢或C.sub.1-3烷基；##STR2##是一个五元或六元饱和碳环；R.sup.10为氢、甲基或羟甲基；R.sup.11、R.sup.12和R.sup.13相同或不同，每个是氢或甲基；R.sup.14为氢、甲基、羟基或羟甲基。
• Benzo[c]curbazole derivatives, compositions and use
  申请人：Burroughs Wellcome Co.

  公开号：US04952597A1

  公开（公告）日：1990-08-28

  The present invention related to anti tumor compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tetracyclic aromatic ring system comprised of 5-membered and 6-membered rings and contains at least one heteroatom and 3 aromatic rings and a total of no more than 18 ring atoms, or a substituted derivative thereof; the heteratom is preferably oxygen, sulfur or nitrogen; when it is nitrogen this is substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

  本发明涉及化合物的抗肿瘤化合物的公式（I）ArCH.sub.2R.sup.1（I）或其单甲基或单乙基醚（公式（I）的化合物包括这些醚，总共不超过29个碳原子）；醚，酯；其酸加成盐；其中Ar是由5个成员和6个成员的环组成的融合四环芳香环系统，并包含至少一个杂原子和3个芳香环，总环原子数不超过18个，或其取代衍生物；杂原子最好是氧，硫或氮；当它是氮时，它被氢，甲基或乙基取代；R.sup.1含有不超过八个碳原子，并且是一个组##STR1##其中m为0或1；R.sup.5为氢；R.sup.6和R.sup.7相同或不同，每个都是氢或C.sub.1-5烷基，可选地被羟基取代；R.sup.8和R.sup.9相同或不同，每个都是氢或C.sub.1-3烷基；##STR2##是一个五个或六个成员的饱和碳环；R.sup.10是氢，甲基或羟甲基；R.sup.11，R.sup.12和R.sup.13相同或不同，每个都是氢或甲基；R.sup.14是氢，甲基，羟基或羟甲基。
• BAIR, KENNETH W.
  作者：BAIR, KENNETH W.

  DOI：——

  日期：——
• Polycyclic compounds, their preparation and formulations containing them
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0182608B1

  公开（公告）日：1993-03-03
• US4797495A
  申请人：——

  公开号：US4797495A

  公开（公告）日：1989-01-10