4-chloro-1'-(2,2-dimethylpropyl)-1-[2-[(6-phenylpyridazin-3-yl)amino]phenyl]spiro[2H-indole-3,4'-piperidine]-7-ol | 1609548-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-chloro-1'-(2,2-dimethylpropyl)-1-[2-[(6-phenylpyridazin-3-yl)amino]phenyl]spiro[2H-indole-3,4'-piperidine]-7-ol
• CAS: 1609548-27-7
• 化学式: C₃₃H₃₆ClN₅O
• 分子量: 554.135
• InChiKey: HHZQQMPHZMXNOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(2-bromophenyl)-4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine] 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三氯化硼 、 四丁基碘化铵 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 32.0h， 生成 4-chloro-1'-(2,2-dimethylpropyl)-1-[2-[(6-phenylpyridazin-3-yl)amino]phenyl]spiro[2H-indole-3,4'-piperidine]-7-ol
  参考文献：
  名称：

  2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists

  摘要：

  Blockade of the P2Y(1) receptor is important to the treatment of thrombosis with potentially improved safety margins compared with P2Y(12) receptor antagonists. Investigation of a series of urea surrogates of the diaryl urea lead 3 led to the discovery of 2-amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y(1) receptor antagonists, among which compound 5a was the most potent and the first non-urea analog with platelet aggregation (PA) IC50 less than 0.5 mu M with 10 mu M ADP. Several 2-amino-1,3,4-thiadiazole analogs such as 5b and 5f had a more favorable pharmacokinetic profile, such as higher C-trough, lower Cl, smaller V-dss, and similar bioavailability compared with 3. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.04.011

文献信息

• 2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists
  作者：Carol H. Hu、Jennifer X. Qiao、Ying Han、Tammy C. Wang、Ji Hua、Laura A. Price、Qimin Wu、Hong Shen、Christine S. Huang、Robert Rehfuss、Ruth R. Wexler、Patrick Y.S. Lam

  DOI：10.1016/j.bmcl.2014.04.011

  日期：2014.6

  Blockade of the P2Y(1) receptor is important to the treatment of thrombosis with potentially improved safety margins compared with P2Y(12) receptor antagonists. Investigation of a series of urea surrogates of the diaryl urea lead 3 led to the discovery of 2-amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y(1) receptor antagonists, among which compound 5a was the most potent and the first non-urea analog with platelet aggregation (PA) IC50 less than 0.5 mu M with 10 mu M ADP. Several 2-amino-1,3,4-thiadiazole analogs such as 5b and 5f had a more favorable pharmacokinetic profile, such as higher C-trough, lower Cl, smaller V-dss, and similar bioavailability compared with 3. (C) 2014 Elsevier Ltd. All rights reserved.