4-(4-morpholinyl)-N-(pyridin-4-ylmethyl)aniline | 355818-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(4-morpholinyl)-N-(pyridin-4-ylmethyl)aniline
• 英文别名: 4-morpholin-4-yl-N-(pyridin-4-ylmethyl)aniline
• CAS: 355818-01-8
• 化学式: C₁₆H₁₉N₃O
• 分子量: 269.34
• InChiKey: YGHPMOCMMSDMAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  37.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase
  申请人：Yale University

  公开号：US20150272939A1

  公开（公告）日：2015-10-01

  The present invention includes a novel high-throughput screen capable of identifying compounds that inhibit JARID1B demethylase activity or JARID1A demethylase activity. The present invention further includes novel inhibitors of JARID1B demethylase activity and/or JARID1A demethylase activity, and methods using the same.