聚苯丙生 | 90409-78-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 聚苯丙生
• 英文名称: Polifeprosan
• 英文别名: 4-[3-(4-carboxyphenoxy)propoxy]benzoic acid;decanedioic acid
• CAS: 90409-78-2
• 化学式: C27H34O10
• 分子量: 518.6
• InChiKey: JVYNJRBSXBYXQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.21
• 重原子数：
  37
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  168
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• ABSORBABLE IRON ALLOY STENT
  申请人：Lifetech Scientific (Shenzhen) Co., Ltd.

  公开号：EP3064232A1

  公开（公告）日：2016-09-07

  The invention discloses an absorbable iron alloy stent, comprising an iron alloy substrate and a degradable polymer in contact with the surface of the substrate, in which the degradable polymer has a weight average molecular weight of more than or equal to 20,000 and less than or equal to 1,000,000 and a polydispersity index of more than 1.0 and less than or equal to 50. After the iron alloy stent is implanted into the body, the degradable polymer degrades to produce a carboxyl group. After the degradable stent is implanted into the human body, the effects of oxygen-consuming corrosion enable the stent both to mainly function as a mechanical support and then to degrade gradually, and the amount of hydrogen produced in the degradation process does not reach the level that can lead to a risk of air embolism.

  本发明公开了一种可吸收铁合金支架，包括铁合金基底和与基底表面接触的可降解聚合物，其中可降解聚合物的重量平均分子量大于或等于20,000且小于或等于1,000,000，多分散指数大于1.0且小于或等于50。铁合金支架植入人体后，可降解聚合物会降解产生羧基。可降解支架植入人体后，在耗氧腐蚀的作用下，支架主要起机械支撑作用，然后逐渐降解，降解过程中产生的氢气量不会达到导致空气栓塞风险的水平。
• ABSORBABLE IRON-BASED ALLOY IMPLANTABLE MEDICAL DEVICE
  申请人：Lifetech Scientific (Shenzhen) Co., Ltd.

  公开号：EP3366325A1

  公开（公告）日：2018-08-29

  An absorbable iron-based alloy implantable medical device comprises an iron-based alloy substrate (11), a degradable polymer coating (16) disposed on the surface of the iron-based alloy substrate (11), and a corrosion inhibition layer (12) disposed on the surface of the iron-based alloy substrate (11). The corrosion inhibition layer (12) can delay early-stage corrosion of the iron-based alloy substrate (11), ensure mechanical performance of a medical device in the early stage of the implantation, prevent degradation of a polymer in the early stage of the implantation of the medical device, and reduce the usage of the degradable polymer, thereby reducing risks of inflammatory reactions.

  一种可吸收铁基合金植入式医疗设备包括铁基合金基板（11）、设置在铁基合金基板（11）表面的可降解聚合物涂层（16）以及设置在铁基合金基板（11）表面的腐蚀抑制层（12）。腐蚀抑制层（12）可以延缓铁基合金基板（11）的早期腐蚀，确保医疗设备在植入早期的机械性能，防止聚合物在医疗设备植入早期降解，减少可降解聚合物的用量，从而降低炎症反应的风险。
• ABSORBABLE IRON-BASED ALLOY MEDICAL DEVICE IMPLANT
  申请人：Lifetech Scientific (Shenzhen) Co., Ltd.

  公开号：EP3400970A1

  公开（公告）日：2018-11-14

  An absorbable iron-based alloy medical device implant, comprising an iron-based alloy substrate (11) and a degradable polymer (13) provided on a surface of an iron-based alloy substrate (11), and a zinc-containing protective member (12) provided on the surface of the iron-based alloy substrate (11). The zinc-containing protective member (12) is either a zinc compound or a mixture comprising the zinc compound and at least one of a phosphate-containing compound, a degradable binder, or a water-soluble binder. The weight ratio of the zinc compound in the mixture is ≥ 20% and < 100%. The zinc-containing protective member (12) can delay corrosion of the iron-based alloy substrate (11) during an early stage of medical device implantation. The iron-based alloy substrate (11) is essentially corrosion-free during the early stage of medical device implantation, and is therefore able to satisfy clinical requirements of mechanical performance during the early stage of medical device implantation.

  一种可吸收铁基合金医疗器械植入物，包括铁基合金基板（11）和设置在铁基合金基板（11）表面的可降解聚合物（13），以及设置在铁基合金基板（11）表面的含锌保护件（12）。含锌保护件（12）是锌化合物或由锌化合物和含磷酸盐化合物、可降解粘合剂或水溶性粘合剂中至少一种组成的混合物。混合物中锌化合物的重量比≥ 20% < 100%。在医疗设备植入的早期阶段，含锌保护部件（12）可以延缓铁基合金基底（11）的腐蚀。在医疗器械植入的早期阶段，铁基合金基板（11）基本上不会被腐蚀，因此能够满足医疗器械植入早期阶段对机械性能的临床要求。
• ABSORBABLE IRON-BASED IMPLANTABLE DEVICE
  申请人：Lifetech Scientific (Shenzhen) Co., Ltd

  公开号：EP3725339A1

  公开（公告）日：2020-10-21

  An absorbable iron-based implantable device, including an iron-based substrate and a hydrophobically-modified high polysaccharide attached to the iron-based substrate. The solubility of the modified high polysaccharide in an organic solvent is increased when hydrophobically modified, this allows great film formation on the iron-based substrate when a coating method such as spraying or dip coating is employed for the preparation of a coating, thus allowing an increased amount of the modified high polysaccharide to be attached to the iron-based substrate. When the absorbable iron-based implantable device is implanted into the body, the degradation of the modified high polysaccharide produces an increased amount of degradation product that reacts with a corrosion product of the iron-based substrate to produce a water-soluble polysaccharide-iron complex, thus reducing the production of an insoluble solid corrosion product.

  一种可吸收的铁基植入装置，包括铁基基底和附着在铁基基底上的疏水改性高多糖。经疏水性改性后，改性高多糖在有机溶剂中的溶解度增加，因此在采用喷涂或浸涂等涂层方法制备涂层时，可在铁基基底上形成大量薄膜，从而使更多的改性高多糖附着在铁基基底上。当可吸收铁基植入装置植入人体后，改性高多糖的降解会产生更多的降解产物，与铁基基底的腐蚀产物反应生成水溶性多糖-铁复合物，从而减少不溶性固体腐蚀产物的产生。
• DRUG ELUTING INSTRUMENT AND PREPARATION METHOD THEREFOR
  申请人：Biotyx Medical (Shenzhen) Co., Ltd.

  公开号：EP3903740A1

  公开（公告）日：2021-11-03

  A drug eluting device and a preparation method thereof are disclosed. The drug eluting device includes a substrate and a drug coating arranged on the substrate. The substrate has an outer wall, side walls, and an inner wall, the drug coating contains active drug and a drug carrier, the active drug is dispersed in the drug carrier, the drug coating covers the outer wall, the side walls, and the inner wall of the substrate, and the content of the active drug on both the outer wall and the side walls are greater than the content on the inner wall; or, the active drug is only distributed on the outer wall and the side walls, and the inner wall does not contain the active drug. The drug eluting device is less prone to the phenomenon of coating falling from the substrate.

  本发明公开了一种药物洗脱装置及其制备方法。药物洗脱装置包括基底和布置在基底上的药物涂层。基底具有外壁、侧壁和内壁，药物涂层含有活性药物和药物载体，活性药物分散在药物载体中，药物涂层覆盖基底的外壁、侧壁和内壁，且外壁和侧壁上的活性药物含量均大于内壁上的含量；或者，活性药物仅分布在外壁和侧壁上，内壁上不含活性药物。这种药物洗脱装置不易出现涂层从基底上脱落的现象。