1-(3-Chlorophenyl)-3-(pyridine-3-carbonylamino)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Chlorophenyl)-3-(pyridine-3-carbonylamino)urea
• 化学式: C₁₃H₁₁ClN₄O₂
• 分子量: 290.709
• InChiKey: VEGQTSRQDLEXSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(3-Chlorophenyl)-3-(pyridine-3-carbonylamino)urea 、 4-氯苯磺酰氯 在 2-tBu-imino-2-Et₂N-1,3-Me₂-1,3,2-diazaphosphorinane-polymer 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 生成 4-chloro-N-(3-chlorophenyl)-N-(5-pyridin-3-yl-[1,3,4]oxadiazol-2-yl)benzenesulfonamide 、 [3-(4-Chloro-benzenesulfonyl)-5-pyridin-3-yl-3H-[1,3,4]oxadiazol-(2E)-ylidene]-(3-chloro-phenyl)-amine
  参考文献：
  名称：

  The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

  摘要：

  Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-ammosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.062
• 作为产物：
  描述：

  3-吡啶甲酰肼 、 间氯苯异氰酸酯 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 1-(3-Chlorophenyl)-3-(pyridine-3-carbonylamino)urea
  参考文献：
  名称：

  The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

  摘要：

  Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-ammosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.062

文献信息

• The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
  作者：Ian R. Baxendale、Steven V. Ley、Marisa Martinelli

  DOI：10.1016/j.tet.2005.03.062

  日期：2005.5

  Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-ammosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products. (c) 2005 Elsevier Ltd. All rights reserved.