N-[acetamido-(4-ethoxyphenyl)methyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[acetamido-(4-ethoxyphenyl)methyl]acetamide
• 化学式: C₁₃H₁₈N₂O₃
• 分子量: 250.298
• InChiKey: PTCMTJBZVBVGJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰胺 、 4-乙氧基苯甲醛 在 gold nanoparticles deposited on MnO₂ nanorod-modified graphene oxide nanocomposite 作用下， 以 neat (no solvent) 为溶剂， 以86%的产率得到N-[acetamido-(4-ethoxyphenyl)methyl]acetamide
  参考文献：
  名称：

  Gold nanoparticles deposited on MnO2 nanorods modified graphene oxide composite: A potential ternary nanocatalyst for efficient synthesis of betti bases and bisamides

  摘要：

  The decoration of novel nanostructures such as nano particle and nanorod on the surface of graphene oxide (GO) generate potential heterogeneous nanocatalyst. Highlighting this, in the present work, we have designed a ternary GO-MnO2-Au nanocomposite by decorating MnO(2)nanorods on the surface of graphene oxide via hydrothermal method, followed by deposition of Au nanoparticles on GO-MnO2 surface. The prepared nanocomposite was thoroughly characterised by different instrumental techniques such as X-Ray diffraction (XRD),Fourier transform infrared spectroscopy (FTIR),Raman spectroscopy, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM), High resolution Transmission electron microscopy (HRTEM), X-Ray photo electron spectroscopy (XPS), N-2 adsorption desorption Brunauer-Emmett-Teller (BET) isotherm and Inductively coupled plasma - optical emission spectrometry (ICP-OES). FESEM and TEM images demonstrated that the MnO2 forms rod like structure having diameter of 60-100 nm and are uniformly distributed over the GO surface. HRTEM image clearly signifies gold (Au) nano particles having diameter of 7 +/- 1.9 nm homogeneously distributed throughout the GO-MnO2 surface. Elementary state of Au and tetravalent nature of Mn as well as reduction of functional group after the decoration was confirmed from XPS studies. The catalyst GO-MnO2-Au was found to be the superior catalyst for synthesis of biologically active molecules such as Beni bases and Bisamides. The high catalytic activity of the materials can be attributed to the small and homogeneous distribution of gold nanoparticles, high redox potential of rod shaped MnO2 and the synergistic effect between GO, MnO2 and Au. All the reaction conditions were optimised by varying catalyst dosage, effect of solvent and temperature, The GO-MnO2-Au was easily recycled with minimal leaching and the product yield was found to be 85-90% after 4th cycle demonstrating the stability and durability of our nanocomposite.

  DOI：

  10.1016/j.mcat.2019.110415