N-[(R)-1-phenylethyl]-2-(phenylthio)propanamide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-[(R)-1-phenylethyl]-2-(phenylthio)propanamide
• 英文别名: (2S)-N-[(1R)-1-phenylethyl]-2-phenylsulfanylpropanamide
• 化学式: C₁₇H₁₉NOS
• 分子量: 285.41
• InChiKey: YNHPVMBPSHYAQM-KGLIPLIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-chloro-N-[(R)-1-phenylethyl]propanamide 、 苯硫酚 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-[(R)-1-phenylethyl]-2-(phenylthio)propanamide 、 N-[(R)-1-phenylethyl]-2-(phenylthio)propanamide
  参考文献：
  名称：

  Diastereoselective sulfur oxidation of 2-thio-3-chloroacrylamides

  摘要：

  Diastereoselective sulfur oxidation in 2-thio-3-chloroacrylamides is described A range of chiral amine auxiliaries was incorporated in the beta-chloroacrylamide, and the efficiency with which the stereochemistry was relayed to the sulfur centre during sulfoxidation was investigated. Diastereomeric ratios of up to 3 3 1 were achieved. (C) 2010 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tetasy.2010.05.004

文献信息

• Diastereoselective sulfur oxidation of 2-thio-3-chloroacrylamides
  作者：Marie Kissane、Simon E. Lawrence、Anita R. Maguire

  DOI：10.1016/j.tetasy.2010.05.004

  日期：2010.4

  Diastereoselective sulfur oxidation in 2-thio-3-chloroacrylamides is described A range of chiral amine auxiliaries was incorporated in the beta-chloroacrylamide, and the efficiency with which the stereochemistry was relayed to the sulfur centre during sulfoxidation was investigated. Diastereomeric ratios of up to 3 3 1 were achieved. (C) 2010 Elsevier Ltd. All rights reserved