N-(4-pyridinylmethyl)butanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(4-pyridinylmethyl)butanamide
• 英文别名: N-(pyridin-4-ylmethyl)butanamide
• 化学式: C₁₀H₁₄N₂O
• mdl: MFCD03374436
• 分子量: 178.23
• InChiKey: FNSGFIUOARCDMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain
  申请人：Merla Beatrix

  公开号：US20080167315A1

  公开（公告）日：2008-07-10

  Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K + channels.

  与公式I对应的替代四氢吡咯吡嗪化合物： 它们的制备方法，包含这些化合物的药物组合物以及利用这些化合物治疗和/或抑制至少部分由KCNQ2/3 K + 通道介导的疼痛和其他疾病或疾病状态的方法。
• Ion Channel Modulators
  申请人：Zelle Robert

  公开号：US20070281937A1

  公开（公告）日：2007-12-06

  The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

  这项发明涉及化合物、包含这些化合物的组合物，以及使用这些化合物和化合物组合物的方法。本文描述的化合物、组合物和方法可用于治疗调节离子通道功能，以及治疗疾病和疾病症状，特别是那些由特定钙通道亚型靶点介导的疾病。
• [EN] GLYCINE B ANTAGONISTS<br/>[FR] ANTAGONISTES DE GLYCINE B
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2013030358A1

  公开（公告）日：2013-03-07

  The invention relates to 4-aminonaphthalene-2-carboxylic acids and 1-amino- isoquinoline-3-carboxylic acids as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

  本发明涉及4-氨基萘-2-羧酸和1-氨基异喹啉-3-羧酸以及它们的药用盐。该发明还涉及一种制备这些化合物的方法。本发明的化合物是甘氨酸B拮抗剂，因此对于控制和预防各种疾病，包括神经系统疾病，是有用的。
• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20170174699A1

  公开（公告）日：2017-06-22

  Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

  本文提供了抑制MAPK磷酸化的化合物，因此可用于治疗癌症和炎症性疾病的组合物和方法。
• [EN] HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS<br/>[FR] COMPOSES HETEROCYCLIQUES PERMETTANT DE PREVENIR ET DE TRAITER DES TROUBLES ASSOCIES A UNE PERTE OSSEUSE EXCESSIVE
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2005000404A2

  公开（公告）日：2005-01-06

  This invention relates to pyrimidine compounds of formula (I), formula (I')’ and formula (I’’): formula (I) and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, R5, U, V, W, X, Y, Z, and n are defined herein. This invention also relates to compositions comprising these compounds and methods for using them. The compounds and compositions of this invention are useful to treat or prevent disorders associated with excessive bone loss, including, without limitation periodontal disease, non-malignant bone disorders (such as osteoporosis, Paget's disease of bone, osteogenesis imperfecta, fibrous dysplasia, and primary hyperparathyroidism) estrogen deficiency, inflammatory bone loss, bone malignancy, arthritis, osteopetrosis, and certain cancer-related disorders (such as hypercalcernia of malignancy (HCM), osteolytic bone lesions of multiple myeloma and osteolytic bone metastases of breast cancer and other metastatic cancers).

  本发明涉及式(I)、式(I')和式(I'')的嘧啶化合物，以及其药学上可接受的盐、溶剂化合物、包合物和前药，其中R1、R2、R3、R4、R5、U、V、W、X、Y、Z和n在此定义。本发明还涉及包含这些化合物的组合物和使用它们的方法。本发明的化合物和组合物对于治疗或预防与骨质过度流失相关的疾病有用，包括但不限于牙周疾病、非恶性骨疾病（如骨质疏松症、骨的帕吉特病、不完全性骨发育不良、纤维性骨发育不良和原发性甲状旁腺功能亢进症）、雌激素缺乏、炎症性骨质流失、骨恶性肿瘤、关节炎、骨质硬化和某些与癌症相关的疾病（如恶性高钙血症、多发性骨髓瘤的溶骨性骨病变和乳腺癌和其他转移性癌症的溶骨性骨转移）。