4,5,6-trimethoxy-3-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-ol | 1059117-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4,5,6-trimethoxy-3-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-ol
• CAS: 1059117-49-5
• 化学式: C₂₁H₂₆O₇
• 分子量: 390.433
• InChiKey: QIVJEPKRLFVSAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4,5,6-trimethoxy-3-(3,4,5-trimethoxyphenyl)indan-1-one 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以58%的产率得到4,5,6-trimethoxy-3-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-ol
  参考文献：
  名称：

  Gallic acid-based indanone derivatives as anticancer agents

  摘要：

  Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC50 = 2.2 mu M), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 mu g/ml, 258 mu M). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.039

文献信息

• Gallic acid-based indanone derivatives as anticancer agents
  作者：Hari Om Saxena、Uzma Faridi、Suchita Srivastava、J.K. Kumar、M.P. Darokar、Suaib Luqman、C.S. Chanotiya、Vinay Krishna、Arvind S. Negi、S.P.S. Khanuja

  DOI：10.1016/j.bmcl.2008.06.039

  日期：2008.7

  Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC50 = 2.2 mu M), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 mu g/ml, 258 mu M). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations. (C) 2008 Elsevier Ltd. All rights reserved.