Methyl 2-diethoxyphosphoryl-2-[4-(trifluoromethyl)phenyl]acetate | 1396980-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-diethoxyphosphoryl-2-[4-(trifluoromethyl)phenyl]acetate
• CAS: 1396980-07-6
• 化学式: C₁₄H₁₈F₃O₅P
• 分子量: 354.263
• InChiKey: RROFGOJYDCYHBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-(tert-butyl(dimethyl)silyloxy)pyridine-4-carbaldehyde 、 Methyl 2-diethoxyphosphoryl-2-[4-(trifluoromethyl)phenyl]acetate 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 、
  参考文献：
  名称：

  Photochemical synthesis of benz[h]isoquinolines

  摘要：

  The synthesis of benz[h]isoquinolines has been achieved using a highly convergent photochemical method. The approach presented provides ready access to biologically active compounds and building blocks not readily available through other methods. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.066
• 作为产物：
  描述：

  methyl 2-bromo-2-(4-(trifluoromethyl)phenyl)acetate 、 亚磷酸三乙酯 反应 2.0h， 生成 Methyl 2-diethoxyphosphoryl-2-[4-(trifluoromethyl)phenyl]acetate
  参考文献：
  名称：

  Photochemical synthesis of benz[h]isoquinolines

  摘要：

  The synthesis of benz[h]isoquinolines has been achieved using a highly convergent photochemical method. The approach presented provides ready access to biologically active compounds and building blocks not readily available through other methods. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.066

文献信息

• Photochemical synthesis of benz[h]isoquinolines
  作者：Belinda M. Abbott、Frank D. Ferrari、Suzannah J. Harnor、John C. Barnes、Rodolfo Marquez

  DOI：10.1016/j.tet.2008.03.066

  日期：2008.5

  The synthesis of benz[h]isoquinolines has been achieved using a highly convergent photochemical method. The approach presented provides ready access to biologically active compounds and building blocks not readily available through other methods. (C) 2008 Elsevier Ltd. All rights reserved.