4-[2-(2,4-Dimethylphenoxy)ethyl]morpholine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[2-(2,4-Dimethylphenoxy)ethyl]morpholine
• 化学式: C₁₄H₂₁NO₂
• mdl: MFCD01308643
• 分子量: 235.32
• InChiKey: ASMMROXACKOGJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• USES OF SALT-INDUCIBLE KINASE (SIK) INHIBITORS
  申请人：Dana Farber Cancer Institute, Inc.

  公开号：EP3536323A1

  公开（公告）日：2019-09-11

  The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III-A) (e.g., urea and carbamate SIK inhibitors of Formula (III)).

  本公开提供了使用盐诱导激酶(SIK)抑制剂，如式(I)的大环SIK抑制剂、式(II)的咪唑基SIK抑制剂和式(III-A)的脲和氨基甲酸酯SIK抑制剂(例如，式(III)的脲和氨基甲酸酯SIK抑制剂)治疗和/或预防炎症性肠病(IBD)和移植物抗宿主病(GVHD)的方法。
• ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
  申请人：Celgene Corporation

  公开号：EP2985281B1

  公开（公告）日：2017-12-27
• MACROCYCLIC KINASE INHIBITORS AND USES THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20170204116A1

  公开（公告）日：2017-07-20

  The present disclosure provides macrocyclic compounds of Formula (I). The provided compounds are able to bind protein kinases and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase in a subject or cell and/or in treating or preventing a disease (e.g., proliferative disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
• US8778874B2
  申请人：——

  公开号：US8778874B2

  公开（公告）日：2014-07-15