1-[2-(3-methylphenoxy)ethyl]-1H-imidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[2-(3-methylphenoxy)ethyl]-1H-imidazole
• 英文别名: 1-[2-(3-methylphenoxy)ethyl]imidazole
• 化学式: C₁₂H₁₄N₂O
• mdl: MFCD01308692
• 分子量: 202.25
• InChiKey: XOANZLYVPWNICU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pyrrolopyrimidine Compounds and Their Uses
  申请人：Brain Christopher Thomas

  公开号：US20090318441A1

  公开（公告）日：2009-12-24

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrrolopyrimidine compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.

  本申请描述了对治疗、预防及/或改善疾病有用的有机化合物，特别是描述了抑制蛋白激酶的吡咯并嘧啶化合物及其衍生物。这些有机化合物在治疗增殖性疾病中是有用的。
• [EN] TRICYCLIC PYRAZOL AMINE DERIVATIVES<br/>[FR] DÉRIVÉS TRICYCLIQUES DE PYRAZOLAMINE
  申请人：MERCK SERONO SA

  公开号：WO2011058149A1

  公开（公告）日：2011-05-19

  This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.

  这项发明涉及到 Formula (I*) 的化合物作为 Pi3k 抑制剂，用于治疗自身免疫疾病、炎症性疾病、多发性硬化等疾病，以及癌症等其他疾病。
• PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF
  申请人：Kawasaki Hisashi

  公开号：US20080312228A1

  公开（公告）日：2008-12-18

  The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

  本发明涉及一种嘧啶化合物或其药学上可接受的盐，其由以下公式[I]所表示，其中每个符号如规范中所定义，并提供了一种治疗或预防不良细胞增殖的方法，包括给予这种化合物。本发明的化合物在抑制不良细胞增殖，特别是抗肿瘤活性方面具有优越性，并且可用作抗肿瘤剂，用于预防或治疗癌症、风湿病等。此外，本发明的化合物在与其他抗肿瘤剂如烷基化剂或代谢拮抗剂联合使用时，可成为更有效的抗肿瘤剂。
• PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES
  申请人：BRAIN Christopher Thomas

  公开号：US20120207763A1

  公开（公告）日：2012-08-16

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrrolopyrimidine compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.

  本申请描述了有机化合物，这些化合物对于治疗、预防和/或改善疾病非常有用，特别是描述了能够抑制蛋白激酶的吡咯吡嗪化合物和衍生物。这些有机化合物在治疗增殖性疾病方面非常有用。
• PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：US20150183812A1

  公开（公告）日：2015-07-02

  The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

  本发明涉及一种由以下式[I]所表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如规范中所定义，以及治疗或预防不良细胞增殖的方法，包括给予这样的化合物。本发明的化合物在抑制不良细胞增殖，特别是抗肿瘤活性方面具有优越性，并且在预防或治疗癌症、风湿病等方面作为抗肿瘤剂非常有用。此外，本发明的化合物在与其他抗肿瘤剂如烷基化剂或代谢拮抗剂联合使用时，可以更有效地作为抗肿瘤剂。