5-双苯基-3-基-2H-四唑 | 188890-74-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-双苯基-3-基-2H-四唑
• 英文名称: 5-([1,1'-biphenyl]-3-yl)-2H-tetrazole
• 英文别名: 5-Biphenyl-3-yl-2H-tetrazole；5-(3-phenylphenyl)-2H-tetrazole
• CAS: 188890-74-6
• 化学式: C₁₃H₁₀N₄
• 分子量: 222.249
• InChiKey: WWPSTJGPSOCQIH-UHFFFAOYSA-N

物化性质

• 沸点：
  461.5±38.0 °C(Predicted)
• 密度：
  1.248±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-双苯基-3-基-2H-四唑 、 3-(bromomethyl)pyridine hydrobromide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以30 %的产率得到3-((5-([1,1'-biphenyl]-3-yl)-2H-tetrazol-2-yl)methyl)pyridine
  参考文献：
  名称：

  [EN] 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
  [FR] 2-PYRAZOLE ANILINES ET ANALOGUES APPARENTÉS POUR INHIBER YAP/TAZ-TEAD

  摘要：

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

  公开号：

  WO2023122780A2
• 作为产物：
  描述：

  3-氰基联苯 在 sodium azide 、 氯化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以85 %的产率得到5-双苯基-3-基-2H-四唑
  参考文献：
  名称：

  [EN] 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
  [FR] 2-PYRAZOLE ANILINES ET ANALOGUES APPARENTÉS POUR INHIBER YAP/TAZ-TEAD

  摘要：

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

  公开号：

  WO2023122780A2

文献信息

• EP1666471A4
  申请人：——

  公开号：EP1666471A4

  公开（公告）日：2008-11-26
• [EN] PROCESS FOR PRODUCING 2'-(1H-TETRAZOL-5-YL)­BIPHENYL-4-CARBALDEHYDE<br/>[FR] PROCEDE DE PRODUCTION DE 2'-(1H-TETRAZOL-5-YL)-BIPHENYL-4-CARBALDEHYDE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2005023785A1

  公开（公告）日：2005-03-17

  　本発明は、２’−シアノビフェニル−４−カルボアルデヒドを、アジド塩と反応させることを含む２’−（１Ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒドの製造方法、２’−シアノビフェニル−４−カルボアルデヒドを、アジド塩と反応させ、２’−（１Ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶を取得し、得られた該結晶をテトラヒドロフラン中に溶解し、高純度結晶を再結晶化させることを含む２’−（１Ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド高純度結晶の製造方法等を提供する。　本発明方法によれば、医薬品の合成中間体として有用な２’−（１Ｈ−テトラゾール−５−イル）ビフェニル−４−カルボアルデヒド結晶を短い工程で、高収率かつ高純度に製造し得る。
• [EN] NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY<br/>[FR] COMPOSÉS NON-STÉROÏDIENS ET STÉROÏDIENS PUISSANTS EN TERMES DE RÉGULATION À LA BAISSE DU RÉCEPTEUR DES ANDROGÈNES ET D'ACTIVITÉ CONTRE LE CANCER DE LA PROSTATE
  申请人：UNIV MARYLAND

  公开号：WO2014165815A2

  公开（公告）日：2014-10-09

  Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (BPH), Kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.
• [EN] 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD<br/>[FR] 2-PYRAZOLE ANILINES ET ANALOGUES APPARENTÉS POUR INHIBER YAP/TAZ-TEAD
  申请人：[en]THE KATHOLIEKE UNIVERSITEIT LEUVEN

  公开号：WO2023122780A2

  公开（公告）日：2023-06-29

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.