(4Z)-2-thiophen-2-yl-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4Z)-2-thiophen-2-yl-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5-one
• 化学式: C₁₂H₇NO₂S₂
• 分子量: 261.3
• InChiKey: KXALDPMLWMNCBR-CLFYSBASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 [(噻吩-2-羰基)氨基]乙酸 以57%的产率得到
  参考文献：
  名称：

  KRASOVITSKIJ B. M.; YUDASHKIN A. V.; LYSOVA I. V.; AFANASIADI L. SH.; LIP+, XIMIYA GETEROTSIKL. SOEDIN., 1979, HO 12, 1624-1627

  摘要：

  DOI：

文献信息

• NOVEL COMPOUND AND COMPOSITION FOR PREVENTION OR TREATMENT OF RESPIRATORY DISEASES COMPRISING SAME AS ACTIVE INGREDIENT
  申请人：Yonsei University, University-Industry Foundation(UIF).

  公开号：EP3949963A1

  公开（公告）日：2022-02-09

  The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.

  本发明涉及一种新化合物，以及包括该新化合物、其E-或Z-异构体、其光学异构体、两种异构体的混合物、其前体、其药用盐或其溶剂结晶体作为活性成分的用于预防或治疗呼吸道疾病的组合物。
• PYRIMIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS
  申请人：Proteologics Ltd.

  公开号：US20130131094A1

  公开（公告）日：2013-05-23

  Pyrimidine deriviatives are ubiquination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders.

  嘌呤衍生物是抑制泛素化的抑制剂，尤其是POSH多肽的泛素连接酶活性，可用于治疗病毒感染和神经系统疾病。
• Small Pyrimidine Derivatives and Methods of Use Thereof
  申请人：EREZ Omri

  公开号：US20110130374A1

  公开（公告）日：2011-06-02

  Provided are pyrimidine derivatives which are ubiquitination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, and are useful for the treatment of cancer, angiogenesis disorders, and inflammatory disorders.
• NOVEL COMPOUND AND METHOD FOR PREVENTING OR TREATING OF RESPIRATORY DISEASES COMPRISING THE SAME AS AN ACTIVE INGREDIENT
  申请人：YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF)

  公开号：US20220193041A1

  公开（公告）日：2022-06-23

  The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.
• US8283355B2
  申请人：——

  公开号：US8283355B2

  公开（公告）日：2012-10-09