2-(dipyridin-2-ylamino)-4-(4-methoxyphenyl)-6-phenylnicotinonitrile | 1392014-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(dipyridin-2-ylamino)-4-(4-methoxyphenyl)-6-phenylnicotinonitrile
• 英文别名: 2-(Dipyridin-2-ylamino)-4-(4-methoxyphenyl)-6-phenylpyridine-3-carbonitrile；2-(dipyridin-2-ylamino)-4-(4-methoxyphenyl)-6-phenylpyridine-3-carbonitrile
• CAS: 1392014-22-0
• 化学式: C₂₉H₂₁N₅O
• 分子量: 455.519
• InChiKey: CHJVAWPPAAOEHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  74.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-溴吡啶 、 2-Amino-4-(4-methoxyphenyl)-6-phenylnicotinonitrile 在 BF₄*C₂₄H₁₈CuN₄⁽¹⁺⁾ 、 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以69%的产率得到2-(dipyridin-2-ylamino)-4-(4-methoxyphenyl)-6-phenylnicotinonitrile
  参考文献：
  名称：

  Expedient N-Arylation for the Synthesis of 2-Arylamino-3-cyanopyridines Using Ionic Copper(I) Complex as a Catalyst

  摘要：

  The N-arylation of 2-amino-3-cyanopyridines is firstly described by using ionic copper(I) complex (Phen)(2)Cu+BF4- (phen = 1,10-phenanthroline) as an efficient catalyst. The synthetic protocol can be applied to synthesize a wide range of 2-arylamino-3-cyanopyridine products in good to excellent isolated yields. The resulted products are potentially building blocks for further preparation of biologically interesting products or useful ligands for metal catalysis.

  DOI：

  10.3987/com-12-12461

文献信息

• Expedient N-Arylation for the Synthesis of 2-Arylamino-3-cyanopyridines Using Ionic Copper(I) Complex as a Catalyst
  作者：Min Zhang、Yuqiang Ding、Biao Xiong、Ting Wang、Fengxia Yan、Xiaoting Wang

  DOI：10.3987/com-12-12461

  日期：——

  The N-arylation of 2-amino-3-cyanopyridines is firstly described by using ionic copper(I) complex (Phen)(2)Cu+BF4- (phen = 1,10-phenanthroline) as an efficient catalyst. The synthetic protocol can be applied to synthesize a wide range of 2-arylamino-3-cyanopyridine products in good to excellent isolated yields. The resulted products are potentially building blocks for further preparation of biologically interesting products or useful ligands for metal catalysis.