N-acetyl-beta-glucosaminyl-N-acetylmuramyl-alanylisoglutamine | 70280-03-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-beta-glucosaminyl-N-acetylmuramyl-alanylisoglutamine
• 英文别名: (4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,5R)-2-acetamido-4-[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,6-dihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid
• CAS: 70280-03-4
• 化学式: C₂₇H₄₅N₅O₁₆
• 分子量: 695.7
• InChiKey: JPBBNLWRCVBGJS-KCAUTNRHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.2
• 重原子数：
  48
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  343
• 氢给体数：
  11
• 氢受体数：
  16

文献信息

• Methods of enhancing immune induction involving MDA-7
  申请人：Board of Regent, The University of Texas System

  公开号：US20040009939A1

  公开（公告）日：2004-01-15

  The present invention relates to compositions and methods for the enhancing or inducing an immune response against an immunogenic molecule by indirectly activating PKR. More specifically, immunotherapy is improved by co-administering a MDA-7 polypeptide with an immunogenic molecule against which an immune response is desired. Such immunotherapies include cancer vaccines, and compositions thereof are described.

  本发明涉及通过间接激活 PKR 来增强或诱导针对免疫原分子的免疫反应的组合物和方法。 更具体地说，通过将 MDA-7 多肽与需要针对其产生免疫反应的免疫原分子共同给药，可改善免疫疗法。 此类免疫疗法包括癌症疫苗及其组合物。
• Methods and compositions involving MDA-7
  申请人：Chada Sunil

  公开号：US20060134801A1

  公开（公告）日：2006-06-22

  The present invention relates to compositions and methods involving MDA-7. More specifically, the present invention is directed to diagnostic, prognostic, and therapeutic treatment compositions and methods for treatment of cancer and other angiogenesis-related disorders (anti-angiogenesis therapy). The present invention is also directed to methods of purification of MDA-7.

  本发明涉及涉及 MDA-7 的组合物和方法。更具体地说，本发明涉及用于治疗癌症和其他血管生成相关疾病（抗血管生成疗法）的诊断、预后和治疗组合物和方法。本发明还涉及 MDA-7 的纯化方法。
• METHODS OF ENHANCING IMMUNE INDUCTION INVOLVING MDA-7
  申请人：BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

  公开号：EP1490101A1

  公开（公告）日：2004-12-29
• EP1490101A4
  申请人：——

  公开号：EP1490101A4

  公开（公告）日：2006-09-20
• METHODS AND COMPOSITIONS INVOLVING MDA-7
  申请人：Board of Regents, The University of Texas System

  公开号：EP1603943A2

  公开（公告）日：2005-12-14