1-acetyl-2-oxoindoline-3-spiro-2'-(5-phenyl-1,3,4-thiadiazole-4-ine) | 113369-17-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-acetyl-2-oxoindoline-3-spiro-2'-(5-phenyl-1,3,4-thiadiazole-4-ine)
• 英文别名: 1-acetyl-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one；1'-acetyl-5-phenylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one
• CAS: 113369-17-8
• 化学式: C₁₇H₁₃N₃O₂S
• 分子量: 323.375
• InChiKey: LHSUSCLSQHTPQM-UHFFFAOYSA-N

物化性质

• 熔点：
  162 °C
• 沸点：
  588.6±60.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-乙酰基靛红 、 苯硫代甲酰肼 以 乙醇 为溶剂， 反应 2.0h， 以20.6%的产率得到1-acetyl-2-oxoindoline-3-spiro-2'-(5-phenyl-1,3,4-thiadiazole-4-ine)
  参考文献：
  名称：

  Tomchin, A. B., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, # 6, p. 1180 - 1187

  摘要：

  DOI：

文献信息

• Thiadiazole compounds and methods of use thereof
  申请人：Bursavich Matthew G.

  公开号：US20080125469A1

  公开（公告）日：2008-05-29

  The present invention relates to Thiadiazole Compounds; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of a Thiadiazole Compound to a mammal in need thereof.

  本发明涉及噻二唑化合物；包含有效剂量噻二唑化合物的组合物；以及治疗或预防金属蛋白酶相关疾病的方法，例如关节炎、骨关节炎、癌症、类风湿性关节炎、哮喘、慢性阻塞性肺病、动脉粥样硬化、老年性黄斑变性、心肌梗死、角膜溃疡、眼表疾病、肝炎、主动脉瘤、肌腱炎、中枢神经系统疾病、异常伤口愈合、血管生成、再狭窄、肝硬化、多发性硬化、肾小球肾炎、移植物抗宿主病、糖尿病、炎症性肠病、休克、椎间盘退行性变、中风、骨质疏松症或牙周疾病，或包括向需要的哺乳动物施用有效剂量噻二唑化合物。
• TOMCHIN, A. B., ZH. ORGAN. XIMII, 23,(1987) N 6, 1305-1312
  作者：TOMCHIN, A. B.

  DOI：——

  日期：——
• THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Wyeth

  公开号：EP2032584A2

  公开（公告）日：2009-03-11
• [EN] ANTIFUNGAL AGENTS<br/>[FR] AGENTS ANTIFONGIQUES
  申请人：F2G LTD

  公开号：WO2005092304A2

  公开（公告）日：2005-10-06

  Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents, wherein: R1, R2 and R3 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
• [EN] THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS DE THIADIAZOLE ET PROCÉDÉS LES UTILISANT
  申请人：WYETH CORP

  公开号：WO2007146138A2

  公开（公告）日：2007-12-21

  [EN] The present invention relates to Thiadiazole Compounds; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age- related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of a Thiadiazole Compound to a mammal in need thereof.
  [FR] La présente invention concerne des composés de thiadiazole ; des compositions comprenant une dose efficace d'un composé de thiadiazole ; et des procédés de traitement ou de prévention d'un trouble lié aux métalloprotéinases tel qu'un trouble arthritique, l'ostéoarthrite, le cancer, la polyarthrite rhumatoïde, l'asthme, la maladie pulmonaire obstructive chronique, l'athérosclérose, la dégénérescence maculaire liée à l'âge, l'infarctus du myocarde, une ulcération cornéenne, une maladie de la surface de l'oel, l'hépatite, un anévrisme aortique, la tendinite, un trouble du système nerveux central, la cicatrisation anormale, l'angiogenèse, la resténose, la cirrhose, la sclérose en plaques, la glomérulonéphrite, la maladie homologue, le diabète, une maladie entérique inflammatoire, le choc, la dégénérescence des disques intervertébraux, l'accident vasculaire cérébral, l'ostéopénie ou une maladie parodontique, comprenant l'administration d'une dose efficace d'un composé de thiadiazole à un mammifère nécessitant un tel traitement.