5-氟-2-(2-氟-4-(甲硫基)苯基氨基)-1-甲基-6-氧代-N-(2-(乙烯基氧基)乙氧基)-1,6-二氢吡啶-3-甲酰胺 | 1057327-07-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-氟-2-(2-氟-4-(甲硫基)苯基氨基)-1-甲基-6-氧代-N-(2-(乙烯基氧基)乙氧基)-1,6-二氢吡啶-3-甲酰胺
• 英文名称: 5-fluoro-2-(2-fluoro-4-(methylthio)phenylamino)-1-methyl-6-oxo-N-(2-(vinyloxy)ethoxy)-1,6-dihydropyridine-3-carboxamide
• 英文别名: N-(2-ethenoxyethoxy)-5-fluoro-2-(2-fluoro-4-methylsulfanylanilino)-1-methyl-6-oxopyridine-3-carboxamide
• CAS: 1057327-07-7
• 化学式: C₁₈H₁₉F₂N₃O₄S
• 分子量: 411.429
• InChiKey: HFTSSWUFRBYWSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5-氟-2-(2-氟-4-(甲硫基)苯基氨基)-1-甲基-6-氧代-N-(2-(乙烯基氧基)乙氧基)-1,6-二氢吡啶-3-甲酰胺 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 16.0h， 以70%的产率得到5-fluoro-2-(2-fluoro-4-(methylthio)phenylamino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  参考文献：
  名称：

  WO2007/44084

  摘要：

  公开号：
• 作为产物：
  描述：

  O-[2-(乙烯氧基)乙基]羟胺 、 methyl 5-fluoro-2-(2-fluoro-4-(methylthio)phenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 生成 5-氟-2-(2-氟-4-(甲硫基)苯基氨基)-1-甲基-6-氧代-N-(2-(乙烯基氧基)乙氧基)-1,6-二氢吡啶-3-甲酰胺
  参考文献：
  名称：

  WO2007/44084

  摘要：

  公开号：

文献信息

• Heterocyclic inhibitors of MEK and methods of use thereof
  申请人：Marlow L. Allison

  公开号：US20070112038A1

  公开（公告）日：2007-05-17

  Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

  本发明涉及公式I和公式V的化合物及其药学上可接受的盐和前药，其中R1、R2、R7、R8和R9、W、X和Y在规范中定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物的高增殖性疾病，如癌症和炎症，以及炎症病状。本发明还涉及使用这些化合物治疗哺乳动物的高增殖性疾病的方法和包含这些化合物的制药组合物。
• HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF
  申请人：Marlow Allison L.

  公开号：US20100063053A1

  公开（公告）日：2010-03-11

  Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

  本发明涉及公式I和V的化合物及其药学上可接受的盐和前药，其中R1、R2、R7、R8和R9、W、X和Y如规范中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物的高增殖性疾病，如癌症和炎症，以及炎症状况。本发明还涉及使用这些化合物治疗哺乳动物的高增殖性疾病的方法和含有这些化合物的制药组合物。
• Heterocyclic Inhibitors of Mek and Methods of Use Thereof
  申请人：Marlow Allison L.

  公开号：US20080280957A1

  公开（公告）日：2008-11-13

  Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

  本发明揭示了MEK抑制剂，其在哺乳动物的高增殖性疾病，如癌症和炎症，以及炎症状况的治疗中有用。还揭示了使用这些化合物治疗哺乳动物高增殖性疾病的方法和含有这些化合物的制药组成物。
• Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
  申请人：Array BioPharma Inc.

  公开号：US07732616B2

  公开（公告）日：2010-06-08

  Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

  本发明揭示了I和V式化合物及其药学上可接受的盐和前药，其中R1、R2、R7、R8和R9、W、X和Y的定义如规范中所述。这些化合物是MEK抑制剂，可用于治疗哺乳动物的高增殖性疾病，如癌症和炎症，以及炎症情况。还揭示了使用这些化合物治疗哺乳动物的高增殖性疾病的方法和包含这些化合物的药物组合物。
• 6-oxo-1,6-dihydropyridine compounds as inhibitors of MEK and methods of use thereof
  申请人：Array BioPharma Inc.

  公开号：US08101639B2

  公开（公告）日：2012-01-24

  Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

  本发明涉及公式I和公式V的化合物及其药学上可接受的盐和前药，其中R1、R2、R7、R8和R9、W、X和Y如规范中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物的高增殖性疾病，如癌症和炎症，以及炎症病症。本发明还涉及使用这些化合物治疗哺乳动物的高增殖性疾病的方法和包含这些化合物的制药组合物。