((4-Aminophenyl)sulfonyl)-L-proline

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ((4-Aminophenyl)sulfonyl)-L-proline
• 英文别名: (2S)-1-(4-aminophenyl)sulfonylpyrrolidine-2-carboxylic acid
• 化学式: C₁₁H₁₄N₂O₄S
• 分子量: 270.31
• InChiKey: XTPPHZWDRNGVTM-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4)<br/>[FR] INHIBITEURS DE PROTÉINE 4 CONTENANT UN BROMODOMAINE (BRD4)
  申请人：ZHOU JIA

  公开号：WO2018112037A1

  公开（公告）日：2018-06-21

  Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.

  某些实施例涉及BRD4溴结构域的小分子选择性抑制剂。本文描述的化合物可用于调节支气管NFκB-BRD4轴，该轴在对病毒分子模式的急性中性粒细胞反应中起作用。本文描述的化合物可作为各种人类疾病和病况的预防和治疗药物开发。
• Inhibitors of bromodomain-containing protein 4 (BRD4)
  申请人：Zhou Jia

  公开号：US11117865B2

  公开（公告）日：2021-09-14

  Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.

  某些实施方式涉及BRD4溴结构域的小分子选择性抑制剂。本文所述化合物可用于调节支气管NFκB-BRD4轴，其在响应病毒分子模式的急性中性粒细胞反应中发挥重要作用。本文所述化合物可开发为预防和治疗多种人类疾病和状况的药物。
• INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4)
  申请人：Zhou, Jia

  公开号：EP3554503A1

  公开（公告）日：2019-10-23