(2R)-2,3-dihydroxypropyl methacrylate | 96557-25-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (2R)-2,3-dihydroxypropyl methacrylate
• 英文别名: [(2S)-2,3-dihydroxypropyl] 2-methylprop-2-enoate
• CAS: 96557-25-4
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: QRIMLDXJAPZHJE-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2R)-2,3-(isopropylidenedioxy)propyl methacrylate 在 溶剂黄146 、 4-甲氧基苯酚 作用下， 反应 0.17h， 以69%的产率得到(2R)-2,3-dihydroxypropyl methacrylate
  参考文献：
  名称：

  Transition-metal-catalyzed asymmetric organic synthesis via polymer-attached optically active phosphine ligands. 13, Asymmetric hydrogenation with polymer catalysts containing primary and chiral secondary pendant alcohols

  摘要：

  DOI：

  10.1021/jo00213a020

文献信息

• DESCHENAUX, R.;STILLE, J. K., J. ORG. CHEM., 1985, 50, N 13, 2299-2302
  作者：DESCHENAUX, R.、STILLE, J. K.

  DOI：——

  日期：——
• NOVEL SUGAR ALCOHOL-BASED COMPOSITIONS FOR DELIVERING NUCLEIC ACID-BASED DRUGS IN VIVO AND IN VITRO
  申请人：Lin, Shi-Lung

  公开号：EP3086812A1

  公开（公告）日：2016-11-02
• [EN] NOVEL SUGAR ALCOHOL-BASED COMPOSITIONS FOR DELIVERING NUCLEIC ACID-BASED DRUGS IN VIVO AND IN VITRO<br/>[FR] NOUVELLES COMPOSITIONS À BASE DE POLYOL POUR UNE ADMINISTRATION IN VIVO ET IN VITRO DE MÉDICAMENTS À BASE D'ACIDES NUCLÉIQUES
  申请人：LIN SHI-LUNG

  公开号：WO2015099839A1

  公开（公告）日：2015-07-02

  This invention relates to a composition and its use for formulating nucleic acid-based drugs/vaccines with sugar alcohol compositions into complexes for both in-vitro and in-vivo delivery. Particularly, the present invention includes the ingredients and processes necessary for formulating therapeutic and pharmaceutical nucleic acid compositions, such as miRNA, microRNA precursors, shRNAs, siRNAs, ribozymes, antisense RNAs/DNAs, RNA-DNA hybrids and DNA vectors/vaccines, with glycylated sugar alcohols/sugars into delivery complexes, which can then be absorbed by cells in vivo and in vitro via active endocytosis. Also, the present invention discloses that chemical compounds containing sugar alcohol- and/or sugar-like structures can protect nucleic acids, in particular miRNAs, shRNAs, siRNAs and ribozymes, from degradation in vivo as well as in vitro. Therefore, the present invention is also a formula and method for preserving the structural integrity and functional efficacy of these nucleic acid-based drugs and/or vaccines in vivo and in vitro.
• [EN] NOVEL TRIMETHYLGLYCYLGLYCERIN COMPOSITIONS AND THEIR USE IN DEVELOPING ANTI-CANCER DRUGS AND RNA VACCINES<br/>[FR] NOUVELLES COMPOSITIONS DE TRIMÉTHYLGLYCYLGLYCÉRINE ET LEUR UTILISATION DANS LE DÉVELOPPEMENT DE MÉDICAMENTS ANTICANCÉREUX ET DE VACCINS À ARN
  申请人：WJWU & LYNN INSTITUTE FOR STEM CELL RES

  公开号：WO2021061192A1

  公开（公告）日：2021-04-01

  This invention generally relates to a group of novel chemical compositions and their use for formulating RNA- and/or DNA-based medicine drugs/vaccines into stable compound complexes useful for both in-vitro and in-vivo delivery. Particularly, the present invention teaches the synthesis of a group of novel trimethylglycyl chemicals and their use for formulating cosmetic, therapeutic- and/or pharmaceutical-grade nucleic acid compositions, including but not limited microRNA precursors (pre-miRNA/miRNA), small hairpin RNAs (shRNA), short interfering RNAs (siRNA), ribozymes, antisense oligonucleotides, RNA-DNA hybrids and DNA-based vectors/vaccines, with or without modification, into delivery complexes, which can then be absorbed by cells in vivo, ex vivo and/or in vitro through an active mechanism of endocytosis via acetylcoline receptors for releasing the therapeutic and pharmaceutical effects of the formulated nucleic acid compositions.
• Transition-metal-catalyzed asymmetric organic synthesis via polymer-attached optically active phosphine ligands. 13, Asymmetric hydrogenation with polymer catalysts containing primary and chiral secondary pendant alcohols
  作者：Robert Deschenaux、John K. Stille

  DOI：10.1021/jo00213a020

  日期：1985.6