(4-amino-3-pyridinyl)phenylmethanone oxime

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (4-amino-3-pyridinyl)phenylmethanone oxime
• 英文别名: (NE)-N-[(4-aminopyridin-3-yl)-phenylmethylidene]hydroxylamine
• 化学式: C₁₂H₁₁N₃O
• 分子量: 213.239
• InChiKey: PPFBNKWEGZCLQJ-NTCAYCPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-amino-3-pyridinyl)phenylmethanone oxime 在 aluminum nickel sodium hydroxide 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 水 、 乙腈 为溶剂， 生成 (4-Amino-3-pyridinyl)benzenemethanamine dihydrochloride
  参考文献：
  名称：

  Aminopyridinylmethanols and aminomethylpyridinamines and related compounds, a process for their preparation and their use as medicaments

  摘要：

  本发明涉及式I的各种化合物，其中X为OH，O，NOH，NH₂，loweralkylamino，cycloalkylamino，arylloweralkylamino或arylamine; R₁为H，loweralkylcarbonyl，arylcarbonyl，arylloweralkylcarbonyl，loweralkyl或arylloweralkyl; R₂为氢，loweralkyl，cycloalkyl，arylloweralkyl，aryl; 当存在R₃时，它为氢，loweralkyl，cycloalkyl，arylloweralkyl或aryl，但如果X为OH或NH₂，则R₁，R₂和R₃不能全部为氢; 如果X = O，则R₂不能为氢，R₁不能为2,2-二甲基丙酰基; 以及它们的制备方法。本发明的化合物可用于治疗各种以胆碱能缺陷为特征的记忆功能障碍，例如阿尔茨海默病，作为治疗各种皮肤病的局部抗炎剂以及作为镇痛剂。

  公开号：

  EP0435222A3

文献信息

• Aminopyridinylmethanols and aminomethylpyridinamines and related compounds, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0435222A3

  公开（公告）日：1991-12-11

  The present invention relates to various compounds of the formula I, where X is OH, O, NOH, NH₂, loweralkylamino, cycloalkylamino, arylloweralkylamino or arylamino; R₁ is H, loweralkylcarbonyl, arylcarbonyl, arylloweralkylcarbonyl, loweralkyl or arylloweralkyl; R₂ is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl, aryl; and R₃ when present is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or aryl with the proviso that, if X is OH or NH₂, R₁, R₂ and R₃ may not all be hydrogen; and if X = O, R₂ may not be hydrogen and R₁ may not be 2,2-dimethylpropionyl; and a process for their preparation.The compounds of the invention are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease, as topical antiinflammatory agents for the treatment of various dermatoses and also as analgesic agents.

  本发明涉及式I的各种化合物，其中X为OH，O，NOH，NH₂，loweralkylamino，cycloalkylamino，arylloweralkylamino或arylamine; R₁为H，loweralkylcarbonyl，arylcarbonyl，arylloweralkylcarbonyl，loweralkyl或arylloweralkyl; R₂为氢，loweralkyl，cycloalkyl，arylloweralkyl，aryl; 当存在R₃时，它为氢，loweralkyl，cycloalkyl，arylloweralkyl或aryl，但如果X为OH或NH₂，则R₁，R₂和R₃不能全部为氢; 如果X = O，则R₂不能为氢，R₁不能为2,2-二甲基丙酰基; 以及它们的制备方法。本发明的化合物可用于治疗各种以胆碱能缺陷为特征的记忆功能障碍，例如阿尔茨海默病，作为治疗各种皮肤病的局部抗炎剂以及作为镇痛剂。
• 4-Substituted dihydropyrido (4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0480155A2

  公开（公告）日：1992-04-15

  There are described compounds of the formula where R1 is hydrogen, loweralkyl, arylloweralkyl or aryl; R2 when present is hydrogen, loweralkyl, arylloweralkyl; and R3 is hydrogen, loweralkyl, cycloalkyl or aryl; which compounds are useful as analgesics and topical antiinflammatory agents for the treatment of skin disorders.

  所述化合物的化学式为 式中 R1 是氢、低级烷基、芳低级烷基或芳基； R2 存在时为氢、低级烷基、芳低级烷基；以及 R3 是氢、低级烷基、环烷基或芳基； 这些化合物可用作治疗皮肤病的镇痛剂和局部消炎剂。
• US5059602A
  申请人：——

  公开号：US5059602A

  公开（公告）日：1991-10-22
• US5095019A
  申请人：——

  公开号：US5095019A

  公开（公告）日：1992-03-10
• 4-substituted dihydropyrido(4,3-d)pyrimidines as analgesics and topical
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05059602A1

  公开（公告）日：1991-10-22

  There are described compounds of the formula ##STR1## where R.sub.1 is hydrogen, loweralkyl, arylloweralkyl or aryl; R.sub.2 when present is hydrogen, loweralkyl, arylloweralkyl; and R.sub.3 is hydrogen, loweralkyl, cycloalkyl or aryl; which compounds are useful as analgesics and topical antiinflammatory agents for the treatment of skin disorders.

  描述了一些化合物的化学式为##STR1## 其中R.sub.1是氢、低碳基、芳基低碳基或芳基；当存在时，R.sub.2是氢、低碳基、芳基低碳基；R.sub.3是氢、低碳基、环烷基或芳基。这些化合物对于治疗皮肤疾病的镇痛剂和局部消炎剂非常有用。