1.3.5-Tris-<2>cumaronyl-benzol | 13685-09-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 1.3.5-Tris-<2>cumaronyl-benzol
• 英文别名: 1,3,5-tri(benzofuran-2-yl)benzene；2,2',2''-benzene-1,3,5-triyl-tris-benzofuran；1,3,5-tribenzofuranylbenzene；2-[3,5-Bis(1-benzofuran-2-yl)phenyl]-1-benzofuran
• CAS: 13685-09-1
• 化学式: C₃₀H₁₈O₃
• 分子量: 426.471
• InChiKey: HLUDYWLDBPKIAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙酰基苯并呋喃 在 Amberlyst 15 作用下， 以 氟苯 为溶剂， 以35%的产率得到1,3-di(benzofuran-2-yl)but-2-en-1-one
  参考文献：
  名称：

  Reusable resin Amberlyst 15 catalyzed new convenient protocol for accessing arylated benzene scaffolds

  摘要：

  Polyarylated benzene derivatives are useful molecular entities in chemical and material sciences owing to their unique photophysical properties associated with them. In this Letter, we report that 2-acetyl-benzofuran in the presence of Amberlyst 15 at reflux temperature furnished a mixture of dimer, trimer. and tetramer with interesting conformational properties. The protocol was generalized to prepare diverse arylated benzene scaffolds in good yields under similar reaction conditions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.029

文献信息

• Benzofuran compounds
  申请人：——

  公开号：US20030105343A1

  公开（公告）日：2003-06-05

  There is disclosed a method of preparing a branched benzofuran compound comprising a core moiety which contains at least one aromatic ring and which has at least three substituted or unsubstituted benzofuran groups covalently linked thereto. The method comprises the steps of (i) forming an intermediate ethynylene compound in which at least three benzene rings are each linked to the core moiety via an ethynylene bond, and where each benzene ring is substituted at the ortho position (relative to the position of the ethynylene bond) by a blocked carbonyloxy group, (ii) deblocking the carbonyloxy groups, and (iii) effecting ring closure by reaction between the deblocked carbonyloxy groups and the adjacent ethynylene bonds to form the furan rings of the benzofuran groups, whereby to produce the branched benzofuran compound.

  公开了一种制备支链苯并呋喃化合物的方法，其包含至少一个芳香环核心基团，且至少有三个取代或未取代的苯并呋喃基团与其共价键合。该方法包括以下步骤：(i)形成中间乙炔基化合物，在该化合物中，至少有三个苯环通过乙炔基键与核心基团连接，且每个苯环在邻位（相对于乙炔基键的位置）处被阻断的羰基氧基团取代，(ii)去除羰基氧基团，以及(iii)通过去除羰基氧基团和相邻乙炔基键之间的反应进行环闭合，形成苯并呋喃基团的呋喃环，从而产生支链苯并呋喃化合物。
• Reusable resin Amberlyst 15 catalyzed new convenient protocol for accessing arylated benzene scaffolds
  作者：Amit Kumar、Manish Dixit、Salil P. Singh、Resmi Raghunandan、Prakas R. Maulik、Atul Goel

  DOI：10.1016/j.tetlet.2009.05.029

  日期：2009.7

  Polyarylated benzene derivatives are useful molecular entities in chemical and material sciences owing to their unique photophysical properties associated with them. In this Letter, we report that 2-acetyl-benzofuran in the presence of Amberlyst 15 at reflux temperature furnished a mixture of dimer, trimer. and tetramer with interesting conformational properties. The protocol was generalized to prepare diverse arylated benzene scaffolds in good yields under similar reaction conditions. (C) 2009 Elsevier Ltd. All rights reserved.