Ethoxycarbonylmethyl methacrylate | 20363-83-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethoxycarbonylmethyl methacrylate
• 英文别名: Ethoxycarbonylmethyl-methacrylat；(2-ethoxy-2-oxoethyl) 2-methylprop-2-enoate
• CAS: 20363-83-1
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: ZQFZSKPXTQMPNC-UHFFFAOYSA-N

物化性质

• 沸点：
  72-79 °C(Press: 3 Torr)
• 密度：
  1.059±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2916140000

反应信息

• 作为产物：
  描述：

  sodium methacrylate 、 溴乙酸乙酯 在 四丁基溴化铵 作用下， 以 乙腈 为溶剂， 以95%的产率得到Ethoxycarbonylmethyl methacrylate
  参考文献：
  名称：

  Efficacy of PolyMPC–DOX Prodrugs in 4T1 Tumor-Bearing Mice

  摘要：

  We report the in vivo efficacy, in tumor-bearing mice, of cancer prodrugs consisting of poly-(methacryloyloxyethyl phosphorylcholine) (polyMPC) conjugated to doxorubicin (DOX). Our synthesis of polyMPC-DOX conjugates established prodrugs with tunable drug loading, pH sensitive release kinetics, and a maximum tolerated dose in the range of 30-50 mg/kg (DOX equivalent) in healthy mice. Here we show prolonged circulation of polyMPC-DOX, with a measured in vivo half-life (t(1/2)) 8 times greater than that of the free drug. We observed reduced drug uptake in healthy tissue, and 2-3 times enhanced drug accumulation in tumors for polyMPC-DOX prodrugs compared to free DOX, using BALB/c mice bearing 4T1 tumors. Prolonged survival and reduced tumor growth were observed in mice receiving the polyMPC-DOX prodrug treatment. Moreover, we evaluated immunogenicity of polyMPC-DOX prodrugs by examining complete blood count (CBC) and characteristic cytokine responses, demonstrating no apparent innate or adaptive immune system response.

  DOI：

  10.1021/mp500009r

文献信息

• POSITIVE-TYPE RESIST COMPOSITION, METHOD FOR FORMING RESIST PATTERN, PHOTO-REACTIVE QUENCHER, AND POLYMERIC COMPOUND
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20160376233A1

  公开（公告）日：2016-12-29

  A positive-type resist composition which generates an acid upon exposure and whose solubility in an alkali developing solution increases under the action of an acid, the composition including a base material component whose solubility in an alkali developing solution increases under the action of an acid; and a compound represented by the following general formula (m0): Z 01 to Z 04 each independently represent a substituent having electron withdrawing properties, Rb 21 and Rb 22 each independently represent an alkyl group, an alicyclic hydrocarbon group which may have a substituent, or a hydroxyl group, Rb 1 represents an aryl group which may have a substituent, an alkyl group, or an alkenyl group, n1 and n2 represent an integer of 0 to 3, and X0 − represents an organic anion.

  一种正型抗蚀组合物，曝光后生成酸，其在碱性显影溶液中的溶解度在酸的作用下增加，该组合物包括一种基材组分，在酸的作用下在碱性显影溶液中的溶解度增加；以及由以下一般式（m0）表示的化合物：Z01至Z04分别独立表示具有电子吸引性的取代基，Rb21和Rb22分别独立表示烷基基团、可能具有取代基的脂环烃基团或羟基，Rb1表示可能具有取代基的芳基、烷基或烯基，n1和n2表示0至3的整数，X0−表示有机阴离子。
• Activated ester monomers and polymers
  申请人：American Cyanamid Company

  公开号：US04778869A1

  公开（公告）日：1988-10-18

  Ethylenically unsaturated monomers containing activated ester groups are used to make polymers and copolymers which are useful in coatings, adhesives and moldings.

  含有活性酯基的乙烯不饱和单体被用于制造聚合物和共聚物，这些聚合物和共聚物在涂料、粘合剂和模塑方面非常有用。
• DUAL-FUNCTIONAL NONFOULING SURFACES AND MATERIALS
  申请人：Jiang Shaoyi

  公开号：US20100099160A1

  公开（公告）日：2010-04-22

  Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

  双重功能的防污表面和材料，制备双重功能防污表面和材料的方法，以及包括双重功能防污表面和材料的设备。双重功能表面是抗非特异性蛋白质吸附和细胞附着的防污表面。双重功能表面和材料包括共价耦合的生物分子（例如，靶向结合伴侣），赋予其特定的生物活性。这些表面和材料在医学诊断、生物材料和生物加工、组织工程和药物传递中非常有用。
• RESIST COMPOSITION FOR IMMERSION EXPOSURE, METHOD OF FORMING RESIST PATTERN, AND FLUORINE-CONTAINING RESIN
  申请人：TAKESHITA Masaru

  公开号：US20120116038A1

  公开（公告）日：2012-05-10

  A resist composition for immersion exposure including: a base component (A) which exhibits changed solubility in an alkali developing solution under the action of acid; an acid-generator component (B) which generates acid upon exposure; and a fluorine-containing resin component (F); dissolved in an organic solvent (S), the fluorine-containing resin component (F) including a structural unit (f1) containing a fluorine atom, a structural unit (f2) containing a hydrophilic group-containing aliphatic hydrocarbon group, and a structural unit (f3) derived from an acrylate ester containing a tertiary alkyl group-containing group or an alkoxyalkyl group.

  一种浸泡曝光用的抗蚀组合物，包括：基础组分（A），在酸的作用下在碱性显影液中表现出改变的溶解度；酸发生器组分（B），在曝光时生成酸；以及含氟树脂组分（F），溶解于有机溶剂（S）中，含氟树脂组分（F）包括一个含有氟原子的结构单元（f1），一个含有亲水基的脂肪烃基的结构单元（f2），以及源自丙烯酸酯的一个三级烷基含有基团或烷氧基烷基含有基团的结构单元（f3）。
• DUAL-FUNCTIONAL NONFOULING SURFACES COMPRISING TARGET BINDING PARTNER COVALENTLY COUPLED TO POLYMER ATTACHED TO SUBSTRATE
  申请人：UNIVERSITY OF WASHINGTON

  公开号：US20140370567A1

  公开（公告）日：2014-12-18

  Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

  双重功能的防污表面和材料，制造双重功能的防污表面和材料的方法，以及包括双重功能的防污表面和材料的设备。双重功能表面是抗非特异性蛋白质吸附和细胞附着的防污表面。双重功能表面和材料包括共价耦合的生物分子（例如，目标结合伙伴），从而赋予其特定的生物活性。这些表面和材料在医学诊断、生物材料和生物加工、组织工程和药物传递中非常有用。