3-methyl-5-phenyl-2,3,4,5-tetrahydro-benzo[d]azepin-7-amine | 98626-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 3-methyl-5-phenyl-2,3,4,5-tetrahydro-benzo[d]azepin-7-amine
• 英文别名: (5R)-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-amine
• CAS: 98626-71-2
• 化学式: C₁₇H₂₀N₂
• 分子量: 252.359
• InChiKey: JNDPGFKINLFTLJ-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-((2,5-二氯嘧啶-4-基)氨基)-N-甲基苯甲酰胺 、 3-methyl-5-phenyl-2,3,4,5-tetrahydro-benzo[d]azepin-7-amine 在 D(+)-10-樟脑磺酸 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 生成 2-((5-chloro-2-((3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
  参考文献：
  名称：

  Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities

  摘要：

  By repurposing a typical dopamine D-1/D-5 receptor agonist motif, C1-substituted-N3-benzazepine or benzazecine, into the classical RTK inhibitor 2,4-diaminopyrimidine skeleton, a series of new 2,4-diarylaminopyrimidine analogues (DAAPalogues) were developed. Compounds 7 and 8a were identified possessing high potency against both c-Met and ALK kinases. Compound 8a displayed appreciable antitumor efficacy at the dose of 1 mg/kg in the ALK-driven BF3/EML4-ALK xenograft mice model.

  DOI：

  10.1021/ml400373j

文献信息

• Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
  申请人：SCHERING CORPORATION

  公开号：EP0135767A1

  公开（公告）日：1985-04-03

  Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepines useful in the treatment of mental disorders such as schizophrenia and depression, and having activities of prolonged duration, are disclosed. Methods for preparing these compounds and methods for their use are also described.

  本发明公开了可用于治疗精神障碍（如精神分裂症和抑郁症）且活性持续时间长的取代型 8-氨基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂卓。还描述了制备这些化合物的方法及其使用方法。
• BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS
  申请人：SCHERING CORPORATION

  公开号：EP0153400A1

  公开（公告）日：1985-09-04
• [EN] BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS
  申请人：SCHERING CORP.

  公开号：WO1985000808A1

  公开（公告）日：1985-02-28

  (EN) Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in the treatment of mental disorders such as schizophrenia and depression, and having activities of prolonged duration. Methods for preparing these compounds and methods for their use are also described.(FR) 8-amino-1-phényl-2,3,4,5-tétrahydro-1H-3-benzazépines substituées utiles pour le traitement d'aliénations mentales comme la schizophrénie et la dépression, et dont la durée d'activité est prolongée. Procédé de préparation de ces composés et procédés d'utilisation de ces derniers.
• Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities
  作者：Zhiqing Liu、Jing Ai、Xia Peng、Zilan Song、Kui Wu、Jing Zhang、Qizheng Yao、Yi Chen、Yinchun Ji、Yanhong Yang、Meiyu Geng、Ao Zhang

  DOI：10.1021/ml400373j

  日期：2014.4.10

  By repurposing a typical dopamine D-1/D-5 receptor agonist motif, C1-substituted-N3-benzazepine or benzazecine, into the classical RTK inhibitor 2,4-diaminopyrimidine skeleton, a series of new 2,4-diarylaminopyrimidine analogues (DAAPalogues) were developed. Compounds 7 and 8a were identified possessing high potency against both c-Met and ALK kinases. Compound 8a displayed appreciable antitumor efficacy at the dose of 1 mg/kg in the ALK-driven BF3/EML4-ALK xenograft mice model.