[6-Acetyloxy-2-methyl-1-(4-methylphenyl)-3-nitroindol-7-yl]methyl acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: [6-Acetyloxy-2-methyl-1-(4-methylphenyl)-3-nitroindol-7-yl]methyl acetate
• 化学式: C21H20N2O6
• mdl: MFCD00846461
• 分子量: 396.4
• InChiKey: PHUMYNOPYMKMNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Cell differntiation inhibiting agent, cell culture method using the same, culture medium, and cultured cell line
  申请人：Miyabayashi Tomoyuki

  公开号：US20050153941A1

  公开（公告）日：2005-07-14

  The object of the present invention is to provide a differentiation inhibiting agent which allows culture of a stem cell or an embryonic stem cell in an undifferentiated state without use of any feeder cell, a method for culturing using the same, a cell culture liquid using the same, and a cell prepared by culturing using this differentiation inhibiting agent. The present invention provides a differentiation inhibiting agent which comprises a low molecular weight compound, especially a tetrahydroisoquinoline derivative, as an active ingredient; a method for safely culturing a stem cell in large scale in undifferentiated state in the absence of feeder cell which comprises culturing a stem cell by using a tetrahydroisoquinoline derivative; a culture liquid for stem cells comprising a tetrahydroisoquinoline derivative; and a cell which is obtained by culture using a tetrahydroisoquinoline derivative as a differentiation inhibiting agent.

  本发明的目的是提供一种抑制分化的药剂，该药剂允许在不使用任何饲养细胞的情况下以未分化状态培养干细胞或胚胎干细胞，以及使用相同药剂进行培养的方法，使用相同药剂的细胞培养液，以及使用这种抑制分化药剂进行培养制备的细胞。本发明提供了一种包含低分子量化合物，特别是四氢异喹啉衍生物作为活性成分的抑制分化药剂；一种安全地在大规模中以未分化状态培养干细胞而无需饲养细胞的方法，其中包括使用四氢异喹啉衍生物培养干细胞；一种包含四氢异喹啉衍生物的干细胞培养液；以及通过使用四氢异喹啉衍生物作为抑制分化药剂进行培养获得的细胞。
• Methods for treating Hepatitis C
  申请人：Karp Mitchell Gary

  公开号：US20080096928A9

  公开（公告）日：2008-04-24

  In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

  根据本发明，已经确定了抑制病毒复制的化合物，优选为丙型肝炎病毒（HCV）复制，同时提供了其使用方法。在本发明的一方面，提供了用于治疗或预防病毒感染的化合物。在本发明的另一方面，提供了用于治疗或预防HCV感染的化合物。
• METHODS FOR TREATING HEPATITIS C
  申请人：Karp Gary Mitchell

  公开号：US20120009142A1

  公开（公告）日：2012-01-12

  In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

  根据本发明，已经鉴定出抑制病毒复制的化合物，优选地是抑制丙型肝炎病毒（HCV）复制的化合物，并提供了使用这些化合物的方法。在本发明的一个方面，提供了用于治疗或预防病毒感染的化合物。在本发明的另一个方面，提供了用于治疗或预防HCV感染的化合物。
• CELL DIFFERENTIATION SUPPRESSING AGENT, METHOD OF CULTURING CELLS USING THE SAME, CULTURE SOLUTION, AND CULTURED CELL LINE
  申请人：Miyabayashi Tomoyuki

  公开号：US20090155906A1

  公开（公告）日：2009-06-18

  The object of the present invention is to provide a differentiation inhibiting agent which allows culture of a stem cell or an embryonic stem cell in an undifferentiated state without use of any feeder cell, a method for culturing using the same, a cell culture liquid using the same, and a cell prepared by culturing using this differentiation inhibiting agent. The present invention provides a differentiation inhibiting agent which comprises a low molecular weight compound, especially a tetrahydroisoquinoline derivative, as an active ingredient; a method for safely culturing a stem cell in large scale in undifferentiated state in the absence of feeder cell which comprises culturing a stem cell by using a tetrahydroisoquinoline derivative; a culture liquid for stem cells comprising a tetrahydroisoquinoline derivative; and a cell which is obtained by culture using a tetrahydroisoquinoline derivative as a differentiation inhibiting agent.

  本发明的目的是提供一种抑制分化的剂，该剂使得干细胞或胚胎干细胞可以在未分化状态下培养，而无需使用任何饲养细胞，以及使用该剂的培养方法、使用该剂的细胞培养液和使用该抑制分化剂培养制备的细胞。本发明提供了一种抑制分化的剂，其包括低分子量化合物，特别是四氢异喹啉衍生物，作为活性成分；一种安全地大规模培养未分化状态的干细胞的方法，该方法通过使用四氢异喹啉衍生物来培养干细胞而不使用饲养细胞；一种包含四氢异喹啉衍生物的干细胞培养液；以及通过使用四氢异喹啉衍生物作为抑制分化剂进行培养获得的细胞。
• CELL DIFFERENTIATION INHIBITING AGENT, CELL CULTURE METHOD USING THE SAME, CULTURE MEDIUM AND CULTURED CELL LINE
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1640449A1

  公开（公告）日：2006-03-29

  The object of the present invention is to provide a differentiation inhibiting agent which allows culture of a stem cell or an embryonic stem cell in an undifferentiated state without use of any feeder cell, a method for culturing using the same, a cell culture liquid using the same, and a cell prepared by culturing using this differentiation inhibiting agent. The present invention provides a differentiation inhibiting agent which comprises a low molecular weight compound, especially a tetrahydroisoquinoline derivative, as an active ingredient; a method for safely culturing a stem cell in large scale in undifferentiated state in the absence of feeder cell which comprises culturing a stem cell by using a tetrahydroisoquinoline derivative; a culture liquid for stem cells comprising a tetrahydroisoquinoline derivative; and a cell which is obtained by culture using a tetrahydroisoquinoline derivative as a differentiation inhibiting agent.

  本发明的目的是提供一种可在不使用任何饲养细胞的情况下培养未分化状态的干细胞或胚胎干细胞的分化抑制剂、使用该抑制剂的培养方法、使用该抑制剂的细胞培养液以及使用该分化抑制剂培养制备的细胞。本发明提供了一种由低分子量化合物，特别是四氢异喹啉衍生物作为活性成分的分化抑制剂；一种在没有饲养细胞的情况下安全地大规模培养未分化状态的干细胞的方法，该方法包括使用四氢异喹啉衍生物培养干细胞；一种含有四氢异喹啉衍生物的干细胞培养液；以及一种使用四氢异喹啉衍生物作为分化抑制剂培养得到的细胞。