benzyl 6-(hydroxyamino)-6-oxohexylcarbamate | 1013424-80-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 6-(hydroxyamino)-6-oxohexylcarbamate
• 英文别名: benzyl N-[6-(hydroxyamino)-6-oxohexyl]carbamate
• CAS: 1013424-80-0
• 化学式: C₁₄H₂₀N₂O₄
• 分子量: 280.324
• InChiKey: KKVDXFQUEXNBDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-苄氧羰基--6-氨基己酸 在 4-甲氨基吡啶 、 N,N'-二异丙基碳二亚胺 、 羟胺 作用下， 以 二氯甲烷 、 水 为溶剂， 以100%的产率得到benzyl 6-(hydroxyamino)-6-oxohexylcarbamate
  参考文献：
  名称：

  Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin

  摘要：

  Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.073

文献信息

• [EN] PSMA IMAGING AGENTS<br/>[FR] AGENTS D'IMAGERIE DU PSMA
  申请人：SIEMENS MEDICAL SOLUTIONS

  公开号：WO2013028664A1

  公开（公告）日：2013-02-28

  Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
• Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin
  作者：Jinil Choi、Jewn Giew Park、Yuan-Ping Pang

  DOI：10.1016/j.tetlet.2007.12.073

  日期：2008.2

  Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields. (C) 2007 Elsevier Ltd. All rights reserved.