N-[[5-(4-methyl-3-nitrophenyl)furan-2-yl]methylideneamino]benzo[e][1]benzofuran-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: N-[[5-(4-methyl-3-nitrophenyl)furan-2-yl]methylideneamino]benzo[e][1]benzofuran-2-carboxamide
• 化学式: C25H17N3O5
• mdl: MFCD02604952
• 分子量: 439.4
• InChiKey: SBSJBKYIAPWHAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER COMPRISING N-METHYLENENAPHTHO[2,1-b]FURAN-2-CARBOHYDRAZIDE DERIVATIVES AS AN ACTIVE INGREDIENT
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US20150182502A1

  公开（公告）日：2015-07-02

  The present invention relates to ethyl(2-methyl-3(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
• US9433607B2
  申请人：——

  公开号：US9433607B2

  公开（公告）日：2016-09-06