cis-3-acetoxy-5-methylcyclopentene

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-3-acetoxy-5-methylcyclopentene
• 英文别名: [(1R,4S)-4-methylcyclopent-2-en-1-yl] acetate
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: WAKVYYULGAIFQO-SVRRBLITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-3-acetoxy-5-methylcyclopentene 在 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以74%的产率得到Acetic acid (1R,2R,3R,4S)-2,3-dihydroxy-4-methyl-cyclopentyl ester
  参考文献：
  名称：

  Explanation for Stereoselectivity of the cis-Dihydroxylation of cis-3,5-disubstituted Cyclopentenes.

  摘要：

  研究发现，顺式-3, 5-二取代环戊烯的顺式二羟基化的立体选择性取决于环戊烯的构象，并可通过立体效应和 Cieplak 效应加以解释。

  DOI：

  10.1248/cpb.42.2653

文献信息

• MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
  申请人：MODERNA THERAPEUTICS

  公开号：US20130156849A1

  公开（公告）日：2013-06-20

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

  本公开提供了包含修改的核酸分子的配方组合，这些核酸分子可能编码蛋白质、蛋白质前体或蛋白质或蛋白质前体的部分或完全加工形式的配方组合。该配方组合还可以包括一个修改的核酸分子和一个传递剂。本发明还提供了用于编码能够调节细胞功能和/或活性的多肽的核酸。
• PHOSPHONUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISORDERS
  申请人：UNIVERSITY COLLEGE CORK

  公开号：US20150291640A1

  公开（公告）日：2015-10-15

  A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, wherein the groups are as defined in the claims. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for treating a viral disorder.

  本发明的第一个方面涉及公式（I）的化合物，或其药学上可接受的盐或前药，其中所述的基团如权利要求所定义。本发明的其他方面涉及包含公式（I）化合物的制药组合物，以及使用公式（I）化合物制备治疗病毒性疾病药物的用途。
• METHODS AND COMPOSITIONS FOR TREATING HIV INFECTIONS
  申请人：Ghosh Arun K.

  公开号：US20100113582A1

  公开（公告）日：2010-05-06

  Described herein are compounds and compositions that are useful in the treatment of HIV, AIDS, and AIDS-related diseases. In addition, compounds are described herein that are capable of inhibiting the dimerization of HIV proteases.
• Isoforms of Pig Liver Esterase
  申请人：Bornscheuer Uwe

  公开号：US20110207186A1

  公开（公告）日：2011-08-25

  The invention relates to novel mutants of γPLE, to vehicles containing the same and to their use in the production of enantiomer-enriched alcohols, carboxylic acids and esters.
• MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF
  申请人：modeRNA Therapeutics

  公开号：US20130115272A1

  公开（公告）日：2013-05-09

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.